We report 2 cases of babesiosis in immunocompetent patients in France. A severe influenza-like disease developed in both patients 2 weeks after they had been bitten by ticks. Diagnosis was obtained from blood smears, and Babesia divergens was identified by PCR in 1 case. Babesiosis in Europe occurs in healthy patients, not only in splenectomized patients.
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http://dx.doi.org/10.3201/eid1701.100737 | DOI Listing |
PLoS Negl Trop Dis
December 2024
Department of Parasitology, Faculty of Veterinary Medicine, University of Fırat, Elazig, Turkey.
Small ruminant babesiosis remains a neglected disease despite causing significant economic losses to sheep and goat herds in many regions around the world. The pathogenesis and clinical manifestations of ovine babesiosis are well-known, but there is a lack of information regarding caprine babesiosis. Since the discovery of the first Babesia spp.
View Article and Find Full Text PDFWe describe a case of autochthonous human Babesia divergens infection in an immunocompetent woman in England. The patient had fever, hemolysis, multiorgan failure, and 18% parasitemia. We confirmed B.
View Article and Find Full Text PDFACS Infect Dis
April 2024
Experimental Chemotherapy Lab, VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.
Endochin-like quinolones (ELQs) define a class of small molecule antimicrobials that target the mitochondrial electron transport chain of various human parasites by inhibiting their cytochrome bc complexes. The compounds have shown potent activity against a wide range of protozoan parasites, including the intraerythrocytic parasites and , the agents of human malaria and babesiosis, respectively. First-generation ELQ compounds were previously found to reduce infection by and in animal models of human babesiosis but achieved a radical cure only in combination with atovaquone and required further optimization to address pharmacological limitations.
View Article and Find Full Text PDFFront Public Health
August 2023
Escuela de Medicina, Universidad Internacional del Ecuador, Quito, Ecuador.
Babesiosis is a protozoan disease acquired by the bite of different species of ticks. More than 100 spp. infect wild and domestic animals worldwide, but only a few have been documented to infect humans.
View Article and Find Full Text PDFProc (Bayl Univ Med Cent)
January 2023
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas.
A 66-year-old immunocompetent man with preceding travel through the Northeastern United States developed Guillain-Barré syndrome. A broad search for infections revealed intraerythrocytic parasites on blood smear and positive polymerase chain reaction for ; elevated IgM/IgG serologies for ; elevated IgM/IgG serologies and qualitative polymerase chain reaction for Epstein-Barr virus; and fecal culture growth of . In this report, we discuss the known or suspected association of these infectious agents with Guillain-Barré syndrome.
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