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Chiral Recognition Mechanism of Benzyltetrahydroisoquinoline Alkaloids: Cyclodextrin-Mediated Capillary Electrophoresis, Chiral HPLC, and NMR Spectroscopy Study.
Molecules
February 2025
Integrative Health and Environmental Analysis Research Laboratory, Department of Analytical Chemistry, Institute of Chemistry, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/A, H-1117 Budapest, Hungary.
The tetrahydroisoquinoline skeleton is a pharmacologically significant core structure containing chiral centers, making enantiomeric separation crucial due to the potentially distinct biological effects of each enantiomer. In this study, laudanosine (-methyl-tetrahydropapaverine) and its three derivatives (6'-bromo-laudanosine, norlaudanosine, and -propyl-norlaudanosine) were synthesized and used as model compounds to investigate chiral recognition mechanisms. Screening over twenty cyclodextrins (CyDs) as chiral selectors in capillary electrophoresis (CE), we found anionic CyDs to be the most effective, with sulfated-γ-CyD (S-γ-CyD) achieving a maximum of 10.
View Article and Find Full Text PDFUsing Mixed Methods to Evaluate Risk Minimisation Programs in Europe and the USA: An Innovative Blueprint.
Drug Saf
March 2025
Veterans Administration (VA) Center for the Study of Healthcare Innovation, Implementation, and Policy, VA Greater los Angeles Healthcare System, Los Angeles, USA.
Background: Significant methodological shortcomings have been documented to date in risk minimisation program evaluations for medicinal products, including overreliance on survey methods alone. Recently updated guidances from the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) recommend the use of frameworks and mixed methods designs to improve the rigor of these assessments.
Objective: The purpose of this paper was to exemplify how a mixed methods approach, guided by an implementation science framework, can be used to design the evaluation of a risk minimisation program.
In vitro study of a siRNA delivery liposome constructed with an ionizable cationic lipid.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Department of Pharmaceutical Engineering, Chemistry and Chemical Engineering, Central South University, Changsha 410083.
Objectives: Small interfering RNA (siRNA) can silence disease-related genes through sequence-specific RNA interference (RNAi). Cationic lipid-based liposomes effectively deliver nucleic acids into the cytoplasm but often exhibit significant toxicity. This study aims to synthesize a novel ionizable lipid, Nε-laruoyl-lysine amide (LKA), from natural amino acids, constructed LKA-based liposomes, and perform physicochemical characterization and cell-based experiments to systematically evaluate the potential of these ionizable lipid-based liposomes for nucleic acid delivery.
View Article and Find Full Text PDFOperationalizing Inclusion of Diverse Older Adults in Aging Services Information.
J Appl Gerontol
March 2025
University of Alabama at Tuscaloosa, Tuscaloosa, AL, USA.
As the United States' population ages, it is also becoming more diverse. The country's Older Americans Act requires county-level offices on aging to be both service and information providers. But it is unclear to what extent offices on aging can identify gaps within the aging services information they provide and improve efforts to meet the information needs of diverse older adults.
View Article and Find Full Text PDFAnger De-escalation: A Standardized Patient Workshop for Third- and Fourth-Year Medical Students.
MedEdPORTAL
March 2025
Associate Professor, Department of Internal Medicine and Office of Medical Education, University of Kentucky College of Medicine and Lexington Veterans Affairs Health Care.
Introduction: During clinical training, medical students frequently encounter angry patients and loved ones but feel inadequately prepared to de-escalate these encounters. This unpreparedness might contribute to feelings of shame and anger among medical students and burnout among practicing physicians. Challenging patient scenarios abound in the standardized patient (SP) literature, but no published didactic tool exists focusing exclusively on identification and nonpharmaceutical management of patient anger with a target audience of senior medical students.
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