Introduction: substance abuse is an important cause of ischemic stroke in the young. This includes over-the-counter dietary supplements and cough and cold remedies, which were reported to be an independent risk factor for hemorrhagic stroke.
Case Report: this article describes a young male patient with acute ischemic infarctions in the posterior inferior cerebellar and posterior cerebral artery territories bilaterally, the right cerebral peduncle, the left pontine tegmentum, and lateral pons following abuse of xylometazoline-containing nasal decongestant for 10 years.
Conclusion: this is the first report in the literature of posterior circulation strokes because of chronic xylometazoline abuse. We hope to contribute to increase knowledge and awareness of the public about these serious complications of cough-and-cold remedies as well as dietary supplements containing sympathomimetics.
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http://dx.doi.org/10.1097/NRL.0b013e3181d2ab04 | DOI Listing |
Drug Test Anal
August 2017
Section of Forensic Chemistry, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
A multi-target method that can detect a broad range of drugs in human hair, such as hypnotics, anxiolytics, analgesics, benzodiazepines, antihistamines, antidepressants, antipsychotics, and anticonvulsants, was developed based on ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The drugs were extracted from 10 mg of washed hair by incubation for 18 h in a 25:25:50 (v/v/v) mixture of methanol/acetonitrile/2 mM ammonium formate (8% acetonitrile, pH 5.3).
View Article and Find Full Text PDFPharmacoepidemiol Drug Saf
April 2016
Children's Hospital, Municipal Hospital St. Georg Leipzig, affiliated to the University of Leipzig, Leipzig, Germany.
Purpose: Although sales of prescribed and over-the-counter (OTC) medication are rising, little is known about individual drug intake. This study was aimed to obtain complementary information about drug intake.
Method: Information on drug utilization was obtained in a female cohort for five different time points (TP): 36th week of pregnancy (n = 622), 7th perinatal week (n = 533), 3rd perinatal month (n = 340), and 1st perinatal (n = 534) and 3rd perinatal year (n = 324) by a validated urine screening method.
Forensic Sci Int
May 2014
University Children's Hospital, Pediatric Endocrinology Division, Adenauerallee 119, Bonn 53113, Germany.
The imidazoline derivative xylometazoline, an alpha-2-adrenergic agonist, is used as non-prescription nasal preparation due to its vasoconstrictive and decongestive properties. Especially in children, an overdose can quickly cause severe central nervous system depression and cardiovascular adverse effects. In three 3-year-old boys (triplets) a xylometazoline intoxication was diagnosed by toxicological analysis.
View Article and Find Full Text PDFPrzegl Lek
April 2013
Zakład Farmakologii Klinicznej Katedry Kardiologii Uniwersytetu Medycznego im. K. Marcinkowskiego w Poznaniu.
The article describes the case of 34-years old man, who has used nasal drops with xylomethazoline for three years. Health consequence of uncontrolled use of the drops and treatment were prescribed. Described problem confirms the need of physicians and pharmacists cooperation to limit the problem of drug-addiction.
View Article and Find Full Text PDFEur Heart J
December 2011
Department of Cardiology, Heilig Hart Ziekenhuis, Wilgenstraat 2, 8800 Roeselare, Belgium.
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