Reactive oxygen species (ROS) are important mediators in many neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. This study tested the neuroprotective effects of spirafolide, a compound purified from the leaves of Laurus nobilis L. (Lauraceae), against dopamine (DA)-induced apoptosis in human neuroblastoma SH-SY5Y cells. Following a 24-h exposure of cells to DA (final conc., 0.6 mM), we observed a marked increase in apoptosis, increased generation of ROS and decreased cell viability. Pretreatment of the cells for 24 h with spirafolide (0.4, 2, and 10 μM) before exposure to DA notably increased cell survival (p < 0.01) and lowered intracellular ROS levels (p < 0.01). These results indicate that spirafolide has neuroprotective effects against DA toxicity. These effects may contribute to the treatment of neurodegenerative diseases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12272-010-1210-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparison of the complications rate of different suture-passing techniques at the time of sacrospinous ligament fixation: a systematic review and meta-analysis.
Arch Gynecol Obstet
December 2024
Research Center for Evidence-Based Medicine, Iranian EBM Centre: A JBI Centre of Excellence, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Objective: This study was designed to assess the complications raised in different suture-passing techniques when fixating the Sacrospinous ligament for pelvic organ prolapse (POP).
Search Strategy: We searched PubMed, Embase, Scopus, Web of Sciences, ProQuest, Google Scholar, and Cochrane Library, and performed a systematic review meta-analysis to assess complications when implementing different suture passings in fixating the sacrospinous ligament.
Selection Criteria: The inclusion and exclusion criteria for literature screening were predetermined to allow for a more rigorous process.
Stability indicating RP-HPLC method development and validation for quantification of impurities in gonadotropin-releasing hormone (Elagolix): Robustness study by quality by design.
Biomed Chromatogr
December 2024
Department of Chemistry, GITAM School of Science, GITAM Deemed to be University, Hyderabad, Telanga, India.
The purpose of this research was to establish and validate a reverse phase HPLC method for the determination of Elagolix impurities in pharmaceutical dosage form. Mobile phase A, consisting of 10 mM sodium dihydrogen phosphate (pH 6.0) and acetonitrile in a 95:5 v/v ratio, and mobile phase B, containing 85:10:5 v/v/v of acetonitrile, Milli-Q water, and methanol, were used to achieve the method's specificity in the analytical column Kromasil 100-C18 (250 mm × 4.
View Article and Find Full Text PDFPreparation and Characterization of Poly(lactic acid)-Based Poly(ethylene glycol) and Daphne Essential Oil-Loaded Smart Nanofibers for Thermal Protection.
ACS Omega
October 2024
Department of Biology, Suleyman Demirel University, Isparta 32260, Turkey.
Phase change material (PCM) stores latent heat energy, and poly(ethylene glycol) (Mw: 4000) (PEG 4000) is also a solid-liquid PCM. PEG and poly(lactic acid) (PLA) polymers are biodegradable. Essential oils are known as plant extracts with antimicrobial properties.
View Article and Find Full Text PDFEffects of Leaf Extract on Healing of Experimentally Induced Wounds in Rabbits.
Vet Med Int
October 2024
Department of Anatomy and Histology, College of Veterinary Medicine, University of Fallujah, Anbar, Iraq.
Wound or injury can be defined as partial or complete separation of the skin, while the healing of the wounds is defined as the sequences of processes by which the skin heals and returns to its normal appearance. This study aims to evaluate the efficacy of leaf extracts on the healing of open wounds in rabbits. Twenty-four healthy rabbits were used, divided randomly into control and treated groups, each consisting of 12 rabbits.
View Article and Find Full Text PDFThe effects of local delivery of laurus nobilis extract and adipose derived stem cells via electrospun gelatin scaffold on spinal cord injury inflammatoradscy response and its regeneration.
Regen Ther
June 2024
Department of Materials Science, Isfahan University of Technology, Isfahan, Iran.
When subjected to injury, the spinal cord's inherent complexity poses significant challenges for effective healing. In this study, gelatin nanofibers loaded with Laurus nobilis extract were developed to serve as a delivery system for adipose-derived stem cells (ADSCs), aiming to explore its potential immunomodulatory effects in a rat model of spinal cord injury. Through a series of in vitro assessments including scanning electron microscopy imaging, cell viability, anti-inflammatory, cell adhesion, biodegradation, and hemocompatibility assays, the characteristics of the delivery system were thoroughly evaluated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!