AI Article Synopsis
- - New compounds called aroylhydrazones (4a-f) were created from an acid hydrazide (3) and different aldehydes or sugars.
- - These aroylhydrazones reacted with malononitrile to form 5-amino-4-cyano-1H-pyrazole derivatives (6a-f).
- - The new compounds were tested for their effectiveness against bacteria and fungi, showing moderate to high inhibition, with the best results from those containing both sugar and pyrazole structures.
Article Abstract
New substituted aroylhydrazones (4a-f) were synthesized from the acid hydrazide (3) and the corresponding aldehyde or aldose. 5-Amino-4-cyano-1H-pyrazole derivatives (6a-f) were prepared by the reaction of the aroylhydrazones (4a-f) with malononitrile. The synthesized compounds were tested for antimicrobial activity against various bacteria and fungi and showed moderate to high inhibition activities. Compounds incorporating a sugar moiety as well as a pyrazolyl ring in their structure displayed the highest antimicrobial activity.
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| http://dx.doi.org/10.1007/s12272-010-1202-5 | DOI Listing |
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