AI Article Synopsis
- This study aimed to compare the safety of diferentes cephalosporins used during cataract surgery.
- 129 patients participated, being randomly assigned to receive one of three cephalosporins (cefazolin, cefuroxime, or ceftazidime) or a control (normal saline), with effects measured on eye health post-surgery.
- Results showed no significant differences in endothelial cell density or retinal thickness between the cephalosporin group and the control, suggesting these antibiotics are safe to use in this surgical context.
Article Abstract
Objective: To compare the safety profiles of intracameral cephalosporins in cataract surgery.
Patients And Methods: In this controlled trial, 129 patients were randomized to one of four groups to receive 1 mg of one of three cephalosporins - cefazolin, cefuroxime, or ceftazidime, or normal saline - given intracamerally during cataract surgery. Central endothelial cell density (ECD) and retinal center point thickness (CPT) were determined by specular microscopy and ocular coherence tomography, respectively, before and at 3 months after surgery.
Results: There were no statistical significant differences in the changes of ECD and CPT between eyes receiving intracameral cephalosporin and control.
Conclusion: The use of intracameral cefazolin, cefuroxime, or ceftazidime (1 mg in 0.1-mL solution) at the time of cataract surgery had no significant effect on ECD and CPT postoperatively.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009998 | PMC |
| http://dx.doi.org/10.2147/OPTH.S15602 | DOI Listing |
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