AI Article Synopsis
- The study aimed to investigate how hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) influence the growth and movement of bovine coronary artery endothelial cells (BCAEC) in a lab setting.
- Researchers cultured BCAECs into control, VEGF, and HGF groups, measuring cell growth with MTT and observing movement through a microscope.
- Results showed that both VEGF and HGF significantly enhanced BCAEC proliferation and migration, with HGF showing a stronger effect compared to VEGF.
Article Abstract
Aim: To study the effects of hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) on proliferation and migration of bovine coronary artery endothelial cells (BCAEC) in vitro.
Methods: BCAECs were isolated and cultured in vitro, and divided into control group, VEGF group and HGF group. BCACEs proliferation were measured using MTT, and their migration was observed using reverse microscope.
Results: The OD value of control, VEGF and HGF group were 0.22 +/- 0.01, 0.40 +/- 0.14, 0.44 +/- 0.15 respectively. The proliferation ratio of BCAECs in VEGF and HGF group was 81.8% +/- 16.9%, 100.0% +/- 21.1% respectively. There was no migration in control group, but significant migration in VEGF and HGF group.
Conclusion: Both VEGF and HGF can promote proliferation and migration of BCAECs, the effect of HGF is stronger than VEGF.
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