We studied seven heavily pretreated HIV-2-infected patients exhibiting a virological failure while receiving a salvage raltegravir-containing regimen. At the time of virological failure, different resistance genetic pathways were observed: T97A-Y143C, Q148K, Q148R, G140S-Q148R, E92Q-Y143R-N155H, and T97A-N155H. Thus, despite a 40% difference in integrase genes between HIV-1 and HIV-2, the genetic pathways leading to raltegravir resistance are similar.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067093 | PMC |
| http://dx.doi.org/10.1128/AAC.00942-10 | DOI Listing |
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