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Endophthalmitis Rates following Secondary Intraocular Lens Surgeries: An 11-year Medicare Fee-For-Service Analysis.
J Cataract Refract Surg
October 2024
The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD.
Article Synopsis
- The study evaluated postoperative endophthalmitis (POE) rates and risk factors in patients undergoing secondary intraocular lens (IOL) implantation for aphakia and IOL exchange, focusing on Medicare beneficiaries in the U.S. from 2011 to 2022.
- The results showed that the 42-day POE rates were 0.35% for secondary IOL implantation and 0.28% for IOL exchange, with higher risks associated with anterior vitrectomy and increased comorbidity.
- The overall POE rate was found to be 0.31%, suggesting that the lack of a posterior capsule during secondary IOL surgeries may contribute to the increased risk compared to standard cataract procedures.
Impact of margin thermal ablation after endoscopic mucosal resection of large (≥20 mm) non-pedunculated colonic polyps on long-term recurrence.
Gut
December 2024
Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, New South Wales, Australia
Background And Aims: The efficacy of colorectal endoscopic mucosal resection (EMR) is limited by recurrence and the necessity for conservative surveillance. Margin thermal ablation (MTA) after EMR has reduced the incidence of recurrence at the first surveillance colonoscopy at 6 months (SC1). Whether this effect is durable to second surveillance colonoscopy (SC2) is unknown.
View Article and Find Full Text PDFMapping biological influences on the human plasma proteome beyond the genome.
Nat Metab
October 2024
Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.
Broad-capture proteomic platforms now enable simultaneous assessment of thousands of plasma proteins, but most of these are not actively secreted and their origins are largely unknown. Here we integrate genomic with deep phenomic information to identify modifiable and non-modifiable factors associated with 4,775 plasma proteins in ~8,000 mostly healthy individuals. We create a data-driven map of biological influences on the human plasma proteome and demonstrate segregation of proteins into clusters based on major explanatory factors.
View Article and Find Full Text PDFBarriers and facilitators of abdominal aortic aneurysm screening in London: A cross-sectional survey.
J Med Screen
August 2024
School of Health Sciences, University of Surrey, Guildford, UK.
Objectives: The aim of this research was to identify patient barriers and facilitators of abdominal aortic aneurysm (AAA) screening in London.
Methods: A survey was distributed to 4211 adults, who had been invited for AAA screening in 2023. Barriers and facilitators were identified by comparing responses between attenders and non-attenders, using univariate logistic regression.
Can optical evaluation distinguish between T1a and T1b esophageal adenocarcinoma: an international expert interobserver agreement study.
Endoscopy
October 2024
Department of Gastroenterology and Hepatology, Westmead Hospital, Sydney, Australia.
Background: Piecemeal endoscopic mucosal resection (EMR) is an acceptable technique for T1a esophageal adenocarcinoma, but en bloc R0 excision is advocated for T1b disease as it may offer a potential cure and mitigate recurrence. Thus, distinguishing between T1a and T1b disease is imperative under current treatment paradigms. We investigated whether expert Barrett's endoscopists could make this distinction based on optical evaluation.
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