Twelve sediment cores were collected in July 2007 in open waters of western Bohai Bay, the Port of Tianjin, and the adjacent estuaries of the Haihe and Yongding Rivers. While overall concentrations of trace metals at incremental depths in these cores met the Marine Sediment Quality (GB18668-2002) criteria of China, the magnitude of both metal enrichment factors (EF) and geoaccumulation indices (I(geo)) suggested that pollution with Ag, Cd, Cr, Cu and Zn was occurring in the estuaries and Port. Risk analysis also suggested that Ag and Ni concentrations were sufficiently elevated as to cause adverse biological effects in the study area. Although metal concentrations in western Bohai Bay were of less concern, a positive relationship between EF values and excess (210)Pb activity for several metals suggested that their concentrations were increasing over time.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.jenvman.2010.11.020 | DOI Listing |
Molecules
September 2024
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China.
Drawing inspiration from the structural resemblance between a natural product -(3-carboxypropyl)-2-acetylpyrrole and phenylbutyric acid, a pioneer HDAC inhibitor evaluated in clinical trials, we embarked on the design and synthesis of a novel array of HDAC inhibitors containing an -linked 2-acetylpyrrole cap by utilizing the pharmacophore fusion strategy. Among them, compound exhibited potential inhibitory activity on HDAC1, and demonstrated notable potency against RPMI-8226 cells with an IC value of 2.89 ± 0.
View Article and Find Full Text PDFEnviron Res
December 2024
School of Earth System Science, Tianjin University, 92 Weijin Road, Tianjin, 300072, China; Tianjin Key Laboratory of Earth Critical Zone Science and Sustainable Development in Bohai Rim, Tianjin University, 92 Weijin Road, Tianjin, 300072, China. Electronic address:
Glaciers play key roles in capturing, storing, and transforming global carbon and nitrogen, thereby contributing markedly to their cycles. However, an integrated mechanistic approach is still lacking regarding glacier's primary producers (PP), in terms of stable dissolved inorganic carbon isotope (δC-DIC) and its relationship with dissolved carbon and nitrogen transformation d ynamic changes/cycling. Here, we sampled waters from glaciers, streams, tributaries, and the Indus River (IR) mainstream in the Upper IR Basin, Western Himalaya.
View Article and Find Full Text PDFJ Hazard Mater
October 2024
School of Civil Engineering, Architecture and Environment, Hubei University of Technology, Wuhan 430068, China.
The joint groundwater pollution prevention and control (GPPC) strategy has been extensively implemented to address the coastal region groundwater pollution challenges in China. However, regional groundwater pollution control and treatment efficiency cannot achieve the expected results due to the lack of regional priority control orders and accurate restoration levels. Thus, this study developed a new region demarcation framework method for delineating GPPC zones, in tandem with a comprehensive pollution index method, the DRASTIC model, source apportionment.
View Article and Find Full Text PDFJ Tradit Complement Med
July 2024
Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine for Diabetes and Its Complications, College of Traditional Chinese Medicine, North China University of Science and Technology, 21 Bohai Road, Tangshan, 063210, China.
Background And Aim: Type-2 diabetes mellitus (T2DM) is mainly characterized by insulin resistance (IR) induced by hyperglycaemia and insufficient insulin secretion. We employed a diabetic fly model to examine the effect and molecular mechanism of Koidz. and Lam.
View Article and Find Full Text PDFMol Imaging Biol
August 2024
Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Purpose: To improve tumor uptake and prolong tumor retention, a novel fibroblast activation protein (FAP) ligand based on a quinoline-based FAP inhibitor (FAPI) conjugated with the Gly-Pro sequence and 1,4,7,10-tetraazacyclododecane-N,N',N″,N‴-tetraacetic acid (DOTA) was radiolabeled with [Ga]GaCl ([Ga]Ga-DOTA-GPFAPI-04). Due to the tumor heterogeneity, this study aimed to further validate the preclinical value of [Ga]Ga-DOTA-GPFAPI-04 PET imaging in tumor mice models with different FAP expression levels.
Methods: [Ga]Ga-DOTA-GPFAPI-04 was synthesized and its partition coefficient was measured.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!