Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S1473-3099(10)70304-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sex Differences in Metabolic Disorders of Aging and Obesity in People with HIV.
Curr HIV/AIDS Rep
November 2024
Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.
Purpose Of Review: As advances in antiretroviral therapy for people with HIV (PWH) have prolonged lifespans, prevalence of aging and obesity related metabolic disorders have increased. The purpose of this review is to summarize recent research assessing sex differences in metabolic disorders among PWH, including weight gain/obesity, steatotic liver disease, insulin resistance/diabetes, dyslipidemia, bone loss/osteoporosis, and sarcopenia.
Recent Findings: A growing body of evidence shows that women with HIV are at increased risk of developing metabolic disorders compared to men, including body weight gain and obesity, type 2 diabetes mellitus, dyslipidemia, bone loss, and sarcopenia, while men with HIV are at higher risk for hepatosteatosis and hepatic fibrosis.
Relationships Between Hepatic Steatosis and Frailty Differ by HIV Serostatus.
J Acquir Immune Defic Syndr
October 2024
Division of Infectious Diseases, UTHealth Houston, Houston, TX.
Background: Frailty is associated with obesity-related comorbidities, but the relationship with nonalcoholic fatty liver disease (NAFLD) in people with HIV has been incompletely described. Our objective was to assess the associations between NAFLD and frailty.
Methods: Cross-sectional and longitudinal analysis of men in the Multicenter AIDS Cohort Study.
Outcomes of Bariatric Surgery in People With Human Immunodeficiency Virus: A Retrospective Analysis From the ATHENA Cohort.
Clin Infect Dis
November 2023
Department of Pharmacy and Radboudumc Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands.
Background: The implications of bariatric surgery (BS) on virologic and metabolic outcomes in people with human immunodeficiency virus (HIV; PWH) on antiretroviral therapy (ART) are unknown.
Methods: Here, we report a retrospective analysis up to 18 months post-BS in PWH from the AIDS Therapy evaluation in The Netherlands (ATHENA) cohort with data from all dutch HIV treating Centers. Primary end points were a confirmed virologic failure (2 consecutive HIV-RNA measurements >200 copies/mL) and the percentage of patients who achieved >20% total body weight loss up to 18 months post-BS.
Obesity-Related Single-Nucleotide Polymorphisms and Weight Gain Following First-Line Antiretroviral Therapy.
Clin Infect Dis
March 2023
Centro de Investigación Biomédica en Red de Enfermedades Infecciosas, Madrid, Spain.
Article Synopsis
- The study examined the link between obesity-related genetic variants and weight gain in people with HIV starting antiretroviral therapy (ART).
- Over 1,000 participants showed an average weight gain of about 2.90 kg after 96 weeks, influenced by factors like female gender and previous AIDS diagnoses.
- Certain genetic variants (ZC3H4 rs3810291 and BCDIN3D/FAIM2 rs7138803) were significantly associated with greater weight gain, suggesting genetics could impact ART-related weight changes.
Effect of HIV and antiretroviral therapy use on body weight changes in a cohort of U.S. veterans living with and without HIV.
HIV Med
February 2023
VA Health Services Research Center of Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, Texas, USA.
Objective: People living with HIV have high rates of obesity and obesity-related comorbidities. Our study sought to evaluate weight trajectory in a retrospective cohort of people living with HIV and matched HIV-negative veterans (controls) and to evaluate risk factors for weight gain.
Methods: This was a retrospective database analysis of data extracted from the VA Corporate Data Warehouse that included people living with HIV (n = 22 421) and age-matched HIV-negative controls (n = 63 072).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!