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2'-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids.
J Virol
January 2025
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Unlabelled: Human noroviruses (HuNoVs) are the leading cause of acute gastroenteritis worldwide. Currently, there are no targeted antivirals for the treatment of HuNoV infection. Histo-blood group antigens (HBGAs) on the intestinal epithelium are cellular attachment factors for HuNoVs; molecules that block the binding of HuNoVs to HBGAs thus have the potential to be developed as antivirals.
View Article and Find Full Text PDFImmunohistochemical identification of ACE-2 (SARS-COV II entry mechanism) in the gastrointestinal tract, kidney and lung of rhesus monkeys (Macaca mulatta) and squirrel monkeys (Saimiri sciureus).
Tissue Cell
December 2024
Laboratory of Teaching and Research in Histology and Comparative Embryology (LEPHEC), Biomedical Institute, Fluminense Federal University, Niterói, RJ CEP 24210-130, Brazil. Electronic address:
SARS-Cov-2 is a corona virus that causes COVID-19 disease, a viral infection responsible for the pandemic decreed by the World Health Organization in March 2020. Angiotensin-converting enzyme 2 (ACE-2) functions as the main receptor for SARS-Cov-2. The study aimed to detect the expression of ACE-2 in the gastrointestinal tract, kidney, and lung in the rhesus monkeys and squirrel monkeys.
View Article and Find Full Text PDFDipeptidyl peptidase 4 is a cofactor for porcine epidemic diarrhea virus infection.
Vet Microbiol
January 2025
College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China. Electronic address:
Article Synopsis
- Porcine epidemic diarrhea virus (PEDV) is extremely deadly for neonatal piglets, with a mortality rate that can reach 100%, causing significant economic losses in the pig industry.
- The study identifies dipeptidyl peptidase 4 (DPP4) as a cofactor that enhances PEDV invasion and replication by mapping its expression in various piglet tissues and showing its distribution in intestinal cells.
- Research indicates that inhibiting DPP4 reduces PEDV infection, and experiments suggest that DPP4 and PEDV interact directly, reinforcing the idea that DPP4 plays a crucial role in the virus’s ability to infect pigs.
Pathogenicity comparison between porcine G9P[23] and G5P[23] RVA in piglets.
Vet Microbiol
December 2024
State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China. Electronic address:
Rotavirus Group A (RVA) is a primary pathogen that causes viral diarrhea in humans and animals. Porcine rotaviruses (PoRVs) are widely epidemic in pig farms in China, causing great economic losses to the swine industry. In the past 30 years, the G5 RVA had been the main epidemic genotype in pig farms worldwide.
View Article and Find Full Text PDFOral bacteriophage therapy effectively prevent and control of Clostridium perfringens type c infections in newborn piglets.
Vet Microbiol
January 2025
College of Animal Science and Technology, Guangxi University, PR China; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, PR China; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning 530004, PR China. Electronic address:
Clostridium perfringens (C. perfringens) type C exhibits strong pathogenicity, often leading to swine dysentery, severely affecting the economic efficiency of the pig farming industry. Bacteriophages as bacterial viruses have many natural advantages and are potent candidates for controlling bacterial infections.
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