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Past innovations and future possibilities in plant chromosome engineering.
Plant Biotechnol J
November 2024
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Article Synopsis
- Plant chromosome engineering allows the transfer of desirable traits into plants by incorporating segments from alien chromosomes, enhancing modern plant breeding.
- Successful examples include rye chromosome segments for disease resistance and innovative techniques like centromere engineering and CRISPR/Cas technology for chromosomal manipulation.
- These advancements broaden the possibilities for genetic improvement in crops, paving the way for future innovations in plant breeding.
The impact of Duostim protocol on pregnancy outcomes in infertile patients: A meta-analysis comparing single and double conventional stimulation cycles.
J Assist Reprod Genet
December 2024
Reproductive Medicine Center, Maternal and Child Health Care Hospital of Yulin, No. 290, Qingning Road, Yulin Guangxi, 537000, China.
Background: The DuoStim protocol has been proposed as an alternative to conventional single and double stimulation cycles in the treatment of infertility. However, its efficacy in improving pregnancy outcomes remains uncertain.
Objective: To systematically evaluate the impact of the DuoStim protocol on pregnancy outcomes in infertile patients by comparing it with single and double conventional stimulation cycles.
Exploring the role of oxidative stress and mitochondrial dysfunction in β-damascone-induced aneuploidy.
Genes Environ
November 2024
Scientific Product Assessment Center, Japan Tobacco Inc., 6-2, Umegaoka, Aoba-Ku, Yokohama, Kanagawa, 227-8512, Japan.
Background: The rose ketone β-damascone (β-Dam) elicits positive results in the in vitro micronucleus (MN) assay using human lymphocytes, but shows negative outcomes in the Ames test and combined in vivo MN and comet assays. This has led to the interpretation that the in vitro MN result is a misleading positive result. Oxidative stress has been suggested as an indirect mode of action (MoA) for in vitro MN formation, with the α, β-unsaturated carbonyl moiety of the β-Dam chemical structure expected to cause misleading positive results through this MoA.
View Article and Find Full Text PDFAneuploidy rates and clinical pregnancy outcomes after preimplantation genetic testing for aneuploidy using the progestin-primed ovarian stimulation protocol or the gonadotropin-releasing hormone antagonist protocol.
J Gynecol Obstet Hum Reprod
February 2025
Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, China; Zhejiang Provincial Clinical Research Center for Obstetrics and Gynecology, 310016 Hangzhou, China. Electronic address:
Objective: To investigate the chromosome abnormality rates and clinical pregnancy outcomes after preimplantation genetic testing for aneuploidy (PGT-A) using either the progestin-primed ovarian stimulation (PPOS) protocol or the gonadotropin-releasing hormone (GnRH) antagonist protocol.
Methods: The study included 431 PGT-A cycles in which controlled ovarian stimulation was performed using the PPOS protocol (n = 320 cycles) or GnRH antagonist protocol (n = 111 cycles) between January 2018 and December 2021. Frozen embryo transfer was subsequently performed in 307 cycles with transferable blastocysts.
A multi-cycle approach via DuoStim is beneficial to treat couples indicated to PGT-M plus PGT-A. A propensity score matching-based case series.
Eur J Obstet Gynecol Reprod Biol
December 2024
IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Rome, Italy.
Objective: To compare DuoStim versus a conventional approach in patients indicated to Preimplantation-Genetic-Testing for both monogenic conditions and aneuploidies (PGT-M + PGT-A).
Study Design: Retrospective case-control study. In 5 years, 132 couples indicated to PGT-M + PGT-A who obtained ≤5 blastocysts after a first retrieval were suggested to undergo a second stimulation in the same ovarian cycle.
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