AI Article Synopsis
- The study investigated the impact of the 2007 regulatory decision to remove the indication for intranasal desmopressin on its prescription patterns among children with urinary incontinence.
- Analyzed claims data from 2004 to 2008 showed a slight overall decrease in desmopressin use, but a significant shift towards oral forms after the regulatory change.
- The findings indicate that following the removal of intranasal desmopressin, prescriptions for the oral medication rose dramatically, highlighting an immediate response in treatment practices.
Article Abstract
Purpose: The indication for the treatment of primary nocturnal enuresis was removed from all intranasal preparations of desmopressin in May 2007. Objective of this study was to examine whether and how fast this regulatory decision changed prescribing in affected children.
Methods: We analyzed claims data of the Gmünder ErsatzKasse (GEK) over the years 2004-2008. All children and adolescents aged 0-18 years who received at least one out-patient diagnosis of urinary incontinence in the corresponding years were included. Our outcome of interest was the proportion of oral desmopressin and its change over time.
Results: A total of 6308 to 7207 children with a mean age of about 8 years were included annually (62-63% were male) and 14 746 packages of desmopressin were analysed (49.9% intranasal; 50.1% oral; 0.01% parenteral preparations). The proportion of patients using desmopressin decreased slightly from 13.9% in 2004 to 12.6% in 2008 ( p for trend = 0.0131). Between January 2004 (39.1%) and December 2006 (41.3%), the proportion of oral forms was nearly constant and doubled after that within a few months to about 80%.
Conclusions: Immediately after the removal of the indication for intranasal desmopressin, an increased prescribing of tablet forms in affected children was found in Germany.
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| http://dx.doi.org/10.1002/pds.2070 | DOI Listing |
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