Cryptococcus gattii causes meningoencephalitis in immunocompetent hosts, occurring endemically in some tropical and subtropical regions. Recently, this fungus was involved in an outbreak in Vancouver Island and British Columbia (Canada). In this temperate region, the VGII type is predominant. The paper describes an autochthonous case of meningoencephalitis by C. gattii VGII in a previously health child in Rio de Janeiro, considered nonendemic region of Brazil. The fungus was identified by biochemical tests and the molecular type was determined by URA5-RFLP. The present report highlights the need for clinical vigilance for primary cryptococcal meningitis in nonendemic areas.
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- Cryptococcosis, caused by environmental fungi, leads to severe pneumonia and systemic infections, especially in immune-compromised individuals, with rising cases seen in immunocompetent hosts due to strain R265.* -
- The study investigates the roles of cytokines IL-22 and IL-23 in managing lung health during R265 infections, revealing their importance in preserving lung barrier integrity and preventing excessive damage.* -
- Findings indicate that IL-22 helps control neutrophil activity and promotes eosinophil presence in the lungs, providing crucial insights into immune response and tissue management during aggressive cryptococcal infections.*
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