Introduction: This study analyses the cases of all bites (including dry bites) caused by Bothropoides jararaca attended at the Vital Brazil Hospital of the Butantan Institute, State of São Paulo, Brazil.
Methods: A retrospective study was conducted of patients bitten by Bothropoides jararaca (n=792) from January 1990 to December 2004. The characteristics of the snake specimen, data related to the accident and clinical manifestations on admission were obtained from patient medical records.
Results: The majority of the cases in this study were caused by female and juvenile snakes. No stomach contents were found in 93.4% of the snake specimens after dissection. No statistical difference was observed between the occurrence of dry bites and the maturity or sex of the snake. The median SVL of snakes in mild and moderate cases was 40.5 cm and in severe cases, SVL increased to 99 cm. Necrosis was more common in the digits of the feet and hands (4.8%) compared to the other body regions (1.8%). A significant difference was verified between severity and a time interval greater than six hours from the bite to hospital admission. A significant association was verified between gingival bleeding and abnormal blood coagulability. In accidents caused by adult snakes, necrosis was more frequent (7.2%) compared to accidents caused by juvenile snakes (1%).
Conclusions: In this work, the association between certain epidemiological data and the evolution of biological parameters in the clinical course of Bothrops sensu latu accidents were highlighted, contributing to the improvement of snake bite assistance.
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http://dx.doi.org/10.1590/s0037-86822010000600011 | DOI Listing |
Toxins (Basel)
December 2024
Immunopathology Laboratory, Butantan Institute, São Paulo 05585-090, Brazil.
Jararhagin-C (JarC) is a protein from the venom of consisting of disintegrin-like and cysteine-rich domains. JarC shows a modulating effect on angiogenesis and remodeling of extracellular matrix constituents, improving wound healing in a mouse experimental model. JarC is purified from crude venom, and the yield is less than 1%.
View Article and Find Full Text PDFToxins (Basel)
November 2024
Facultad de Ciencias Exactas y Naturales, Pontificia Universidad Católica del Ecuador, Quito 170525, Ecuador.
Previous proteomic studies of viperid venom revealed that it is mainly composed of metalloproteinases (SVMPs), serine proteinases (SVSPs), phospholipase A2 (PLA2), and C-type lectins (CTLs). However, other proteins appear in minor amounts that affect prey and need to be identified. This study aimed to identify novel toxic proteins in the venom gland transcriptome of and , using data from NCBI.
View Article and Find Full Text PDFToxicon
November 2024
Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Rio de Janeiro, RJ, Brazil. Electronic address:
Globally, about 2.5 million people are victims of snakebites annually. In Brazil, the most clinically relevant snake is the Bothrops jararaca.
View Article and Find Full Text PDFToxicon
November 2024
Laboratorio de Toxinopatología, Departamento de Patología, Facultad de Medicina, José E. Uriburu 950, 5(to) piso (1114), Universidad de Buenos Aires, Buenos Aires, Argentina; Instituto Nacional de Producción de Biológicos I.N.P.B. - A.N.L.I.S. ''Dr. Carlos G. Malbrán'', Ministerio de Salud, Av. Vélez Sarsfield 563 (1282), Buenos Aires, Argentina; Área Investigación y Desarrollo - Venenos, Aracnario-Serpentario. Instituto Nacional de Producción de Biológicos, A.N.L.I.S. "Dr. Carlos G. Malbrán", Av. Velez Sarsfield 563 (1282). Buenos Aires, Argentina. Electronic address:
In this work, we describe an easy, simple, and cost-effective method to assess the proteolytic activity of snake venoms. The method is based on measuring the hydrolytic halo formed by gelatin radial hydrolysis following the incubation of venoms on a solid gelatin-agarose plate. Venoms from Bothrops (B.
View Article and Find Full Text PDFUltrasound Med Biol
January 2025
Laboratory of Pathophysiology Experimental, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma, Brazil. Electronic address:
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