Objective: Liquid chromatography with refractive index (RI) detection has been found to be very useful for the determination of menthol from pharmaceutical products. A simple and rapid HPLC method has been developed for this purpose compared to conventional GC methods, requiring no special sample pretreatment for the determination of menthol from pharmaceutical products.
Materials And Methods: A chromatographic separation was achieved on a Inertsil ODS 3V (4.6mm×250mm, 5μm) column using water : methanol (30:70 v/v) as a mobile phase, at a flow rate of 1.0 ml/min.
Results: Method was validated as per ICH guidelines for various parameters such as precision, linearity, accuracy, solution stability, robustness, limit of detection and quantification. Results were found to be within acceptable limits.
Conclusion: The method has been successfully applied for the quantification of menthol from syrup formulations. The developed method can be conveniently used by the quality control department to determine assay of menthol from pharmaceutical preparations.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996065 | PMC |
| http://dx.doi.org/10.4103/0975-7406.72141 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prescription Design of Sinomenine Gel Based on Molecular Dynamics Simulations.
Int J Mol Sci
November 2024
School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China.
Sinomenine (SIN) is a drug for the treatment of rheumatoid arthritis, most of which is administered orally, but it is prone to adverse gastrointestinal effects. Gel can overcome the gastrointestinal adverse effects caused by oral administration. In this paper, a multiscale computational pharmaceutics strategy was developed to guide the systematic study of formulation factors of a SIN gel and, further, to guide the formulation design.
View Article and Find Full Text PDFLeveraging machine learning to predict drug permeation: impact of menthol and limonene as enhancers.
Mol Divers
December 2024
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, 147002, India.
The present study aimed to develop robust machine learning (ML) models to predict the skin permeability of poorly water-soluble drugs in the presence of menthol and limonene as penetration enhancers (PEs). The ML models were also applied in virtual screening (VS) to identify hydrophobic drugs that exhibited better skin permeability in the presence of permeation enhancers i.e.
View Article and Find Full Text PDFOptical Control of TRPM8 Channels with Photoswitchable Menthol.
Angew Chem Int Ed Engl
December 2024
Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Goethestr. 33, 80336, Munich, Germany.
Transient receptor potential melastatin 8 (TRPM8) channels are well known as sensors for cold temperatures and cooling agents such as menthol and icilin and these channels are tightly regulated by the membrane lipid phosphoinositol-4,5-bisphosphate (PIP). Since TRPM8 channels emerged as promising drug targets for treating pain, itching, obesity, cancer, dry eye disease, and inflammation, we aimed at developing a high-precision TRPM8 channel activator, to achieve spatiotemporal control of TRPM8 activity with light. In this study, we designed, synthesized and characterized the first photoswitchable TRPM8 activator azo-menthol (AzoM).
View Article and Find Full Text PDFNeural modulation by nicotine aerosols and the role of flavor additives: insights from local field potentials in mice.
Neuropharmacology
February 2025
School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, 100083, PR China; Beijing Life Science Academy, Beijing, 102209, PR China. Electronic address:
Article Synopsis
- Research on nicotine aerosols has been limited, prompting this study to investigate their neurobiological effects in mice using in vivo electrophysiology.
- Nicotine exposure led to a significant decrease in brain activity in specific frequency bands (NAc-Alpha, NAc-Beta, and BLA-Beta), and flavor additives did not affect this reduction.
- However, adding citric acid or menthol restored coherence between important brain regions, indicating these flavors may help counteract nicotine's negative impact on neural synchronization.
Evaluating MIR and NIR Spectroscopy Coupled with Multivariate Analysis for Detection and Quantification of Additives in Tobacco Products.
Sensors (Basel)
October 2024
Scientific Direction Chemical and Physical Health Risks, Service of Medicines and Health Products, Sciensano, Rue Juliette Wytsmanstraat 14, B-1050 Brussels, Belgium.
The detection and quantification of additives in tobacco products are critical for ensuring consumer safety and compliance with regulatory standards. Traditional analytical techniques, like gas chromatography-mass spectrometry (GC-MS), liquid chromatography-mass spectrometry (LC-MS), and others, although effective, suffer from drawbacks, including complex sample preparation, high costs, lengthy analysis times, and the requirement for skilled operators. This study addresses these challenges by evaluating the efficacy of mid-infrared (MIR) spectroscopy and near-IR (NIR) spectroscopy, coupled with multivariate analysis, as potential solutions for the detection and quantification of additives in tobacco products.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!