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[Effect and mechanism of chimonin on pulmonary hypertention of chronic hypoxia and hypercapnic rats]. | LitMetric
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[Effect and mechanism of chimonin on pulmonary hypertention of chronic hypoxia and hypercapnic rats].

Xiao-Ying Huang Liang-Xing Wang Ming Li Shao-Xian Chen Zheng-Jie Xu Qun-Ji Wang

Zhongguo Ying Yong Sheng Li Xue Za Zhi

Department of Respirology, First Hospital, Wenzhou Medical College, Wenzhou 325003, China.

Published: February 2002

AI Article Synopsis

  • The study investigates the impact of chimonin on chronic hypoxia and hypercapnic pulmonary hypertension in rats, focusing on its mechanisms.
  • The research involves dividing rats into three groups—normal control, hypoxic hypercapnic, and hypoxic hypercapnic with chimonin—while assessing pulmonary arterioles through various microscopic techniques.
  • Findings indicate that chimonin significantly reduces elevated mean pulmonary arterial pressure and improves conditions related to vascular structure and smooth muscle density, primarily by increasing the expression of HO-1 mRNA.

Article Abstract

Aim: To study the effect of chimonin on chronic hypoxia and hypercapnic pulmonary hypertension and to explore its mechanism.

Methods: SD rats were randomly divided into normal control group (A), hypoxic hypercapnic group(B), hypoxic hypercapnia + chimonin group (C). HO-1 and HO-1 mRNA was observed in pulmonary arterioles of rats by the technique of immunohistochemistry and in situ hybridization.

Results: (1) mPAP was significantly higher in rats of B group than that of A and C group. Differences of mCAP were not significant in three groups. (2) Blood CO concentration was significantly higher in rats of B group than that of A group, it was significantly higher in rats of C group than that of B group. (3) Light microscopy showed that WA/TA (vessel wall area/total area), SMC (the density of medial smooth muscle cell) and PAMT (the thickness of medial smooth cell layer) were significantly higher in rats of B group than those of A and C group. (4) Electron microscopy showed proliferation of medial smooth muscle cells and collagenous fibers of pulmonary arterioles in rats of B group, and chimonin could reverse the changes mentioned above. (5) HO-1 and HO-1 mRNA in pulmonary arterioles was significantly higher in rats of B group than that of A group, they were significantly higher in rats of C group than that of B group.

Conclusion: Chimonin can inhibit hypoxic hypercapnia pulmonary hypertension and pulmonary vessel remodeling by further increasing the expression of HO-1 mRNA.

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