Since the association between nephrogenic systemic fibrosis (NSF) and gadolinium contrast agents (Gd-CAs) was suggested in 2006, several experimental studies have been published to elucidate the role of these agents in the pathogenesis of NSF. Low stability Gd-CAs have a stimulant effect on human skin and fibroblasts in culture and modulate the production of collagen by these cells. Low stability agents have also induced NSF-like skin changes in a rat model with normal renal function after multiple repeat administrations. The role of the 5/6 subtotal nephrectomy rat model in investigating NSF remains under evaluation.
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| http://dx.doi.org/10.4329/wjr.v2.i11.427 | DOI Listing |
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- In 2023-2024, the American Society of Neuroradiology reviewed recent research on GBCA safety to update guidelines for MRI contrast use in CKD patients.
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