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Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy.
Nat Commun
November 2024
Skin and Endothelium Research Division, Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Article Synopsis
- This study investigates the diversity of cancer-associated fibroblasts (CAFs) in various skin cancers, including basal cell carcinoma, squamous cell carcinoma, and melanoma, using advanced analysis techniques.
- Researchers identify three CAF subtypes: myofibroblast-like RGS5+ CAFs, matrix CAFs (mCAFs), and immunomodulatory CAFs (iCAFs), noting that their patterns change with tumor severity.
- The study suggests that targeting specific CAF subtypes could improve the effectiveness of immunotherapy in treating skin cancers, as these cells play distinct roles in tumor progression and immune responses.
Deep Convolutional Neural Network for Accurate Classification of Myofibroblastic Lesions on Patch-Based Images.
Head Neck Pathol
October 2024
Faculdade de Odontologia de Piracicaba, Universidade de Campinas (FOP-UNICAMP), Piracicaba, São Paulo, Brazil.
Objective: This study aimed to implement and evaluate a Deep Convolutional Neural Network for classifying myofibroblastic lesions into benign and malignant categories based on patch-based images.
Methods: A Residual Neural Network (ResNet50) model, pre-trained with weights from ImageNet, was fine-tuned to classify a cohort of 20 patients (11 benign and 9 malignant cases). Following annotation of tumor regions, the whole-slide images (WSIs) were fragmented into smaller patches (224 × 224 pixels).
Myofibroma with Atypical Features can Mimic Low-Grade Myofibroblastic Sarcoma: Two Paediatric Cases.
Indian J Otolaryngol Head Neck Surg
October 2024
Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Av Do Café, S/n Campus USP, Ribeirão Preto, São Paulo, CEP: 14040-904 Brazil.
Myofibroma is a rare benign mesenchymal tumor that frequently affects the pediatric population with a predilection for the head and neck region. About 10% of myofibroma cases, presenting atypical features, can be misinterpreted as low-grade myofibroblastic sarcoma (LGMS), with therapeutic and prognostic impact. Here, we report two pediatric cases of benign myofibroblastic tumors, one of them showing typical characteristics of myofibroma, the other was an atypical myofibroma, which initially mimicked low-grade myofibroblastic sarcoma.
View Article and Find Full Text PDFSurgical Management of a Rare Case of Low-Grade Myofibroblastic Sarcoma of the Larynx.
Indian J Otolaryngol Head Neck Surg
October 2024
Department of Otolaryngology, Head and Neck Surgery, 940th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Lanzhou, China.
Article Synopsis
- Low-grade myofibroblastic sarcoma (LGMS) of the larynx is a very rare type of cancer.
- A 59-year-old man was diagnosed with LGMS after experiencing progressive hoarseness and a mass in the right side of his larynx.
- After undergoing a total laryngectomy, there was no recurrence of the cancer during the 6-month follow-up period.
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