A robust route to 2,4-disubstituted pyrrole heterocycles relying upon a cascade reaction is reported. The reaction benefits from operational simplicity: it is air and moisture tolerant and is performed at ambient temperature. Control over the reaction conditions provides ready access to isopyrroles, 2,3,4-trisubstituted pyrroles, and 3-substituted pyrollidin-2-ones.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043142 | PMC |
| http://dx.doi.org/10.1021/ja110117g | DOI Listing |
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