During the last decade, biogerontologists have labored to understand the biological basis of the aging process by studying the genes and signaling pathways that regulate it. But the last year has seen a breakthrough in a different direction: toward treatments that might slow aging by mimicking the effects of dietary restriction.
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Precision nutrition-based interventions for the management of obesity in children and adolescents up to the age of 19 years.
Cochrane Database Syst Rev
January 2025
Cornell Joan Klein Jacobs Center for Precision Nutrition and Health, Cornell University, Ithaca, NY, USA.
Background: Precision nutrition-based methods develop tailored interventions and/or recommendations accounting for determinants of intra- and inter-individual variation in response to the same diet, compared to current 'one-size-fits-all' population-level approaches. Determinants may include genetics, current dietary habits and eating patterns, circadian rhythms, health status, gut microbiome, socioeconomic and psychosocial characteristics, and physical activity. In this systematic review, we examined the evidence base for the effect of interventions based on precision nutrition approaches on overweight and obesity in children and adolescents to help inform future research and global guidelines.
View Article and Find Full Text PDFFeeding disruptions lead to a significant increase in disease modules in adult mice.
Heliyon
January 2025
CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Feeding disruption is closely linked to numerous diseases, yet the underlying molecular mechanisms remain an important but unresolved issue at the molecular level. We hypothesize that, at the network level, dietary disruptions can alter gene co-expression patterns, leading to an increase in disease-associated modules, and thereby elevating the likelihood of disease occurrence. Here, we investigate this hypothesis using transcriptomic data from a large cohort of adult mice subjected to feeding disruptions.
View Article and Find Full Text PDFAssociations of neighbourhood food retail with disability and death in older adults: Cardiovascular Health Study.
BMJ Nutr Prev Health
December 2024
Urban Health Collaborative, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA.
Background: A healthier diet is associated with lower chronic disease burden, but the impact of neighbourhood food environments on disability and death in older adults is not known.
Methods: In the Cardiovascular Health Study, a cohort study of adults aged 65+, we calculated study years until death (years of life (YOL)), study years without activities of daily living (ADL) difficulty (years of able life; YoAL) and percent of study years without ADL difficulty (compression of disability). Linear regression quantified associations of food establishments within 5 km of baseline home address (as a z-score) with each outcome, adjusted for sociodemographic characteristics.
Assessing ChatGPT's Capability in Addressing Thyroid Cancer Patient Queries: A Comprehensive Mixed-Methods Evaluation.
J Endocr Soc
January 2025
Division of Endocrinology, Metabolism and Diabetes, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Context: Literature suggests patients with thyroid cancer have unmet informational needs in many aspects of care. Patients often turn to online resources for their health-related information, and generative artificial intelligence programs such as ChatGPT are an emerging and attractive resource for patients.
Objective: To assess the quality of ChatGPT's responses to thyroid cancer-related questions.
Is there anything left to eat? A lived experience insight of following a restrictive type 1 diabetes and dialysis diet.
Expert Rev Endocrinol Metab
January 2025
Faculty of Health and Social Sciences, Bournemouth University, UK.
Objectives: Chronic kidney disease has a global morbidity burden of >10%, with diabetes being a major cause. Nutrition therapy is vital in managing both chronic conditions, yet CKD dietary guidelines contradict healthy eating advice, and can result in major psychological and social burdens. Few studies investigate the patient's experience of being placed on such a restrictive diet.
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