Objective: The aim of the study was to evaluate a novel infrared imaging device coupled with an intelligent software interface that may provide a more objective means of identifying anatomical sites at risk for pressure ulcer (PrU) development as compared with the Braden Scale for Predicting Pressure Sore Risk.
Design: Repeated-measures design.
Setting: Duke University Medical Center.
Participants: One hundred patients admitted to a medical unit at risk for PrUs.
Main Results: Only 5 participants developed early stage PrUs (Stages I and II). However, the infrared imaging device not only predicted all 5 participants to be at risk, but also predicted the anatomical location where the ulcer would develop. The Braden Scale correctly identified 3 of 5 participants who developed PrUs. It was also determined that a temperature variance of 1.5° C was able to accurately predict PrU development.
Conclusion: Infrared imaging using intelligent software may become a promising, objective method for identifying incipient PrUs and provide clinicians with specific anatomical locations for increased preventive interventions.
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http://dx.doi.org/10.1097/01.ASW.0000392925.83594.50 | DOI Listing |
J Pharm Biomed Anal
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Institute of Chemistry, University of Silesia in Katowice, 9 Szkolna Street, Katowice 40-006, Poland; SPIN-Lab Centre for Microscopic Studies on Matter, University of Silesia in Katowice, 75 Pulku Piechoty Street 1, Chorzow 41-500, Poland. Electronic address:
Near-infrared hyperspectral imaging (NIR-HSI) integrated with expert systems can support the monitoring of active pharmaceutical ingredients (APIs) and provide effective quality control of tablet formulations. However, existing quality control methods usually test a limited number of variability sources affecting the final product. This study examines the potential of NIR-HSI (in the spectral range of 935.
View Article and Find Full Text PDFJ Nanobiotechnology
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School of Medical Imaging, Xuzhou Medical University, Xuzhou, 221004, China.
With the progress of atherosclerosis (AS), the arterial lumen stenosis and compact plaque structure, the thickening intima and the narrow gaps between endothelial cells significantly limit the penetration efficiency of nanoprobe to plaque, weakening the imaging sensitivity and therapy efficiency. Thus, in this study, a HO-NIR dual-mode nanomotor, Gd-doped mesoporous carbon nanoparticles/Pt with rapamycin (RAPA) loading and AntiCD36 modification (Gd-MCNs/Pt-RAPA-AC) was constructed. The asymmetric deposition of Pt on Gd-MCNs catalyzed HO at the inflammatory site to produce O, which could promote the self-motion of the nanomotor and ease inflammation microenvironment of AS plaque.
View Article and Find Full Text PDFJ Am Chem Soc
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School of Physics and Optoelectronic Engineering, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Colloidal quantum dots (QDs) are promising emitters for biological applications because of their excellent fluorescence, convenient surface modification, and photostability. However, the toxic cadmium composition in the state-of-the-art QDs and their inferior properties in the aqueous phase greatly restrict further use. The performance of water-soluble indium phosphide (InP) QDs lags far behind those of Cd-containing counterparts due to the lack of effective surface protection.
View Article and Find Full Text PDFInt J Biol Macromol
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Key Laboratory of State Administration of Traditional Chinese Medicine, Dongguan HEC Cordyceps R&D Co., Ltd., Dongguan, Guangdong 523850, China; College of Medical Imaging Laboratory and Rehabilitation, Xiangnan University, Chenzhou, Hunan 423000, China. Electronic address:
Cultivated Chinese cordyceps, an optimal substitute for the endangered wild resource, has recently been produced on a large scale. This work sought to explore the structural features and immunomodulatory activity of a novel low-molecular-weight polysaccharide (CSP1a, 15.7 kDa) isolated from cultivated Chinese cordyceps.
View Article and Find Full Text PDFInt J Pharm
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The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi'an Jiaotong University, No.157 Xiwu Road, Xi'an, Shaanxi 710004, China. Electronic address:
Both photothermal therapy (PTT) and chemodynamic therapy (CDT) are designed to focus their antitumor effect on only the tumor site, thereby minimizing unwanted severe damage to healthy tissue outside the tumor. However, each monotherapy is limited in achieving complete tumor eradication, resulting in tumor recurrence. The combination of multiple therapies may help to overcome the limitations of single therapy, improve the chances of complete tumor eradication, and reduce the risk of recurrence.
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