Purpose: The purpose of the present investigation was to examine acoustic voice changes across the life span. Previous voice production investigations used small numbers of participants, had limited age ranges, and produced contradictory results.
Method: Voice recordings were made from 192 male and female participants 4-93 years of age. Acoustic measures of fundamental frequency (F0), sound pressure level (SPL), and signal-to-noise ratio (SNR) were made. Coefficients of variation for F0, SPL, and SNR served as measures of variability. Variables were analyzed separately with stepwise regressions, using age and sex as predictors.
Results: Differences in F0 and SNR across the life span were sex specific. Male and female participants demonstrated significant nonlinear trends for F0, but the trends were stronger for male participants. Female participants demonstrated a similar nonlinear trend for SNR, whereas male participants demonstrated linear increases in SNR with age. Variability of F0, SPL, and SNR followed nonlinear trends, higher at younger and older ages.
Conclusions: Changes in voice production occur throughout the life span, often in a nonlinear way and differently for male and female individuals. Higher variability of acoustic measures of voice in both young and old speakers reflects changes in anatomic structure, physiologic mechanisms, and motor control.
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http://dx.doi.org/10.1044/1092-4388(2010/10-0036) | DOI Listing |
Viruses
November 2024
Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3BX, UK.
Favipiravir (FVP) and remdesivir (RDV) have demonstrable antiviral activity against SARS-CoV-2. Here, the efficacy of FVP, RDV, and FVP with RDV (FVP + RDV) in combination was assessed in Syrian golden hamsters challenged with SARS-CoV- 2 (B.1.
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December 2024
Department of Medicine, University of Patras, 26504 Rio, Greece.
Background/objectives: Research on respiratory virus immunity duration post-vaccination reveals variable outcomes. This study performed a literature review to assess the efficacy and longevity of immune protection post-vaccination against SARS-CoV-2, influenza, and respiratory syncytial virus (RSV), with a focus on immunocompromised populations. Specific objectives included examining humoral and cellular immune responses and exploring the impact of booster doses and hybrid immunity on extending protection.
View Article and Find Full Text PDFVaccines (Basel)
December 2024
Country Office for the Dominican Republic, Pan American Health Organization (PAHO)/World Health Organization (WHO), Ensanche La Fé, Santo Domingo 10514, Dominican Republic.
Vaccination is one of the most effective measures to prevent influenza illness and its complications. Since the 1980s, countries and territories in the Americas have progressively implemented influenza vaccination operations in high-risk priority groups-such as older adults, pregnant persons, persons with comorbidities and health workers. In this review, we present the history and progress of the seasonal influenza program in the Americas, how the program contributed to the efficient and timely roll-out of the COVID-19 vaccines during the pandemic, and how the program can be used to promote immunization operations across the life span for existing and future vaccines.
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December 2024
Research Center for Translational Medicine, Sirius University of Science and Technology, Federal Territory Sirius, Krasnodarsky Krai, Sirius 354349, Russia.
Preventive medicine has proven its long-term effectiveness and economic feasibility. Over the last century, vaccination has saved more lives than any other medical technology. At present, preventative measures against most infectious diseases are successfully used worldwide; in addition, vaccination platforms against oncological and even autoimmune diseases are being actively developed.
View Article and Find Full Text PDFSensors (Basel)
December 2024
The State Key Laboratory for the Safety, Long-Life, Health Operation and Maintenance of Long-Span Bridges, Jiangsu Provincial Institute of Traffic Science (JSTI Group), Nanjing 210098, China.
The strain data acquired from structural health monitoring (SHM) systems of large-span bridges are often contaminated by a mixture of temperature-induced and vehicle-induced strain components, thereby complicating the assessment of bridge health. Existing approaches for isolating temperature-induced strains predominantly rely on statistical temperature-strain models, which can be significantly influenced by arbitrarily chosen parameters, thereby undermining the accuracy of the results. Additionally, signal processing techniques, including empirical mode decomposition (EMD) and others, frequently yield unstable outcomes when confronted with nonlinear strain signals.
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