New 7-(2-aminoethyl)-7H-benzo[4,5]indolo[2,3-b]quinoxalines (13-20) were synthesized with high yields starting from 3H-benzo[e]indole-1,2-dione. These compounds were screened for the cytotoxicity, anti-viral activity, interferon inducing ability and DNA affinity compared with the corresponding 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxaline derivatives (1-12). It was shown, that compounds 13-20 bind to DNA stronger (lg Кa=6.23-6.87) than compounds 1-12 (lg Кa=5.57-5.89). Anti-viral activity is significantly reduced with annulations of benzene ring in Indoloquinoxaline moiety 13-20.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejmech.2010.11.040 | DOI Listing |
Publication Analysis
Top Keywords
anti-viral activity
8
synthesis biological
4
biological activity
4
activity 7h-benzo[45]indolo[23-b]-quinoxaline
4
7h-benzo[45]indolo[23-b]-quinoxaline derivatives
4
derivatives 7-2-aminoethyl-7h-benzo[45]indolo[23-b]quinoxalines
4
7-2-aminoethyl-7h-benzo[45]indolo[23-b]quinoxalines 13-20
4
13-20 synthesized
4
synthesized high
4
high yields
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!