Palladium-catalyzed cross-coupling of polyfluoroarenes with simple arenes.

Org Lett

Beijing National Laboratory of Molecular Sciences (BNLMS), College of Chemistry and Green Chemistry Center, Peking University, Beijing 100871, China.

Published: January 2011

The most efficient method to construct biaryls is the direct dehydrogenative cross-coupling of two different aromatic rings. Such an ideal cross arylation starting from distinct polyfluoroarenes and simple arenes was presented. The selectivity of the cross-coupling was controlled by both of the electronic property of fluoroarenes and steric hindrance of simple arenes. Diisopropyl sulfide was essential to promote the efficacy.

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Source
http://dx.doi.org/10.1021/ol102688eDOI Listing

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