Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.gie.2010.10.017 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Galangin Triggers Eryptosis and Hemolysis Through Ca Nucleation and Metabolic Collapse Mediated by PKC/CK1α/COX/p38/Rac1 Signaling Axis.
Int J Mol Sci
November 2024
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 12372, Saudi Arabia.
Anticancer drugs cause anemia in patients through eryptosis and hemolysis. We thus studied the in vitro toxicity of galangin (GAL) in red blood cells (RBCs). RBCs were exposed to 50-500 μM of GAL and analyzed for markers of eryptosis and hemolysis.
View Article and Find Full Text PDFMorphogen-driven differentiation is precluded by physical confinement in human iPSCs spheroids.
Front Bioeng Biotechnol
November 2024
Centre for Gene Therapy and Regenerative Medicine, King's College London, London, United Kingdom.
Introduction: Cell lineage specification is tightly associated with profound morphological changes in the developing human embryo, particularly during gastrulation. The interplay between mechanical forces and biochemical signals is poorly understood.
Methods: Here, we dissect the effects of biochemical cues and physical confinement on a 3D model based on spheroids formed from human induced pluripotent stem cells (hiPSCs).
Combination of lipopolysaccharide and polygalacturonic acid exerts antitumor activity and augments anti-PD-L1 immunotherapy.
Int J Biol Macromol
November 2024
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 210023 Nanjing, China; Jiangsu Province Academy of Traditional Chinese Medicine, 210028 Nanjing, China. Electronic address:
Article Synopsis
- Polygalacturonic acid (PGA) improved gut microbiota diversity and boosted T cell activity in tumors, enhancing cancer treatment effectiveness.
- When orally administered with a lipopolysaccharide-encapsulated therapy (LPS/PPP), PGA significantly inhibited CT26 tumor growth by 67.6% and rebalanced gut microbiota.
- The combination therapy (PGA_LPS) also increased T cell responses, reduced immunosuppressive cells, and worked well with αPD-L1 immunotherapy, suggesting a promising strategy to boost anti-cancer treatments.
Serum-derived protein coronas affect nanoparticle interactions with brain cells.
Nanotechnology
September 2024
School of Life Sciences, University of Technology Sydney, Sydney, NSW 2007, Australia.
Neuronanomedicine is an emerging field bridging the gap between neuromedicine and novel nanotherapeutics. Despite promise, clinical translation of neuronanomedicine remains elusive, possibly due to a dearth of information regarding the effect of the protein corona on these neuronanomedicines. The protein corona, a layer of proteins adsorbed to nanoparticles following exposure to biological fluids, ultimately determines the fate of nanoparticles in biological systems, dictating nanoparticle-cell interactions.
View Article and Find Full Text PDFLoss of Opi3 causes a lipid imbalance that influences the virulence traits of but not cryptococcosis.
Front Cell Infect Microbiol
August 2024
Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
The basidiomycete fungus is a useful model for investigating mechanisms of fungal pathogenesis in mammalian hosts. This pathogen is the causative agent of cryptococcal meningitis in immunocompromised patients and is in the critical priority group of the World Health Organization fungal priority pathogens list. In this study, we employed a mutant lacking the gene encoding a methylene-fatty-acyl-phospholipid synthase to characterize the role of phosphatidylcholine (PC) and lipid homeostasis in the virulence of .
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!