AI Article Synopsis

  • This study explores how neuronal cell transplantation affects neurogenesis (the formation of new neurons) after a stroke in rats, specifically following middle cerebral artery occlusion (MCAO).
  • It builds on previous findings that transplanting neuronal precursors from human embryonic stem cells can reduce brain damage and improve recovery.
  • Results showed that transplantation increased neurogenesis in a specific brain area (ipsilateral subventricular zone) but not in other regions, indicating that such therapies might influence the brain's natural ability to generate new neurons post-stroke.

Article Abstract

Little is known about the relationship between neuronal cell transplantation and endogenous neurogenesis after experimental stroke. We found previously that transplantation of neuronal precursors derived from BG01 human embryonic stem cells reduced infarct volume and improved behavioral outcome after distal middle cerebral artery occlusion (MCAO) in rats. In this study, transplantation was performed 14 days after distal MCAO and doublecortin (Dcx)-expressing cells in the subventricular zone (SVZ) and subgranular zone of dentate gyrus (SGZ) were counted 60 days post-transplant. Transplantation increased neurogenesis (Dcx expression) in ipsilateral SVZ, but not in contralateral SVZ or either SGZ, in both young adult (3-month-old) and aged (24-month-old) rats. These findings suggest that cell-based therapy for stroke may be associated with changes in endogenous adaptive processes, including neurogenesis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057169PMC
http://dx.doi.org/10.1016/j.brainres.2010.12.037DOI Listing

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