AI Article Synopsis
- A study evaluated body fat changes in HIV patients switching from lopinavir/ritonavir (LPV/r) to atazanavir/ritonavir (ATV/r), involving 37 patients switching and 46 continuing with LPV/r.
- After one year, the ATV/r group showed a significant increase in trunk fat (0.87 kg) and a higher percentage of patients with total fat increases (37.8% for ATV/r vs. 15.2% for LPV/r).
- CT scans indicated that the increase in fat for the ATV/r group was significant in both visceral (28%) and subcutaneous (42%) abdominal fat, suggesting the switch leads to more trunk fat accumulation.
Article Abstract
Changes in body fat distribution in virologically suppressed HIV-infected patients switching from lopinavir/ritonavir (LPV/r) to atazanavir/ritonavir (ATV/r) were assessed. A prospective comparative study was conducted of 37 patients receiving LPV/r regimens switching to ATV/r with 46 patients continuing with LPV/r. Body composition was assessed with whole-body dual-energy x-ray absorptiometry (DXA). Abdominal CT scans were also performed in a subset of patients. Groups were comparable in baseline demographic, clinical, and anthropometric characteristics. After 12 months, peripheral fat did not change significantly, but an increase in trunk fat was observed only in the ATV/r group (0.87 kg, p = 0.021). The percentage of patients with an increase ≥20% in total fat was 37.8% and 15.2% in the ATV/r and LPV/r groups, respectively (p = 0.018). In the ATV/r group, the increase in trunk fat (9.4%) was significantly higher than in peripheral fat (3.7%) (p = 0.007), leading to a significant increase in fat mass ratio (3.76%, p = 0.028), whereas no significant differences were found among LPV/r patients. CT scans showed that abdominal fat increase corresponded to both visceral (28%, p = 0.008) and subcutaneous fat (42%, p = 0.008). These data suggest that switching from LPV/r to ATV/r is associated with increased trunk fat, both subcutaneous and visceral.
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| http://dx.doi.org/10.1089/AID.2010.0254 | DOI Listing |
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