AI Article Synopsis
- The study investigates the impact of aspirin on pulmonary hypertension caused by chronic low oxygen (hypoxia) and high carbon dioxide (hypercapnia) in rats.
- Results show that rats exposed to hypoxia and hypercapnia (Group B) had significantly higher mean pulmonary artery pressure (mPAP) and vessel wall thickness compared to control groups, indicating more severe hypertension and vessel changes.
- The findings suggest that aspirin may help reduce the severe effects of hypoxic hypercapnia on pulmonary hypertension and related vascular remodeling.
Article Abstract
Aim: To study the effect of aspirin on chronic hypoxia and hypercapnic pulmonary hypertension.
Methods: SD rats were randomly divided into normal control group (A), hypoxic hypercapnic group (B), hypoxic hypercapnia + aspirin group (C). The concentration of TXB2 and 6-keto-PGF1alpha in plasma and in lung were detected by the technique of radioimmunology.
Results: (1) mPAP was significantly higher in B group than those of A and C group. Differences of mCAP were not significant in three groups. (2) Light microscopy showed that WA/TA (vessel wall area/total area) and PAMT (the thickness of medial smooth cell layer) were significantly higher in B group than those of A and C group. (3) The concentration of TXB2 and 6-keto-PGF1alpha in plasma and lung as well as the ratio of TXB2/6-keto-PGF1alpha were significantly higher in rats of B group than those of A and C group.
Conclusion: Aspirin may inhibit hypoxic hypercapnia pulmonary hypertension and pulmonary vessel remodeling.
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