AI Article Synopsis
- The Epstein-Barr virus (EBV) is known to play a significant role in developing lymphomas after transplantation, but not all cases involve EBV, indicating other contributing factors.
- The authors suggest that the interaction between the immune cells from the donor and the host may create an environment conducive to lymphoma development post-transplant.
- They propose that host-donor immunologic microchimerism, which involves the coexistence of donor and recipient immune cells, could also be a significant yet under-recognized factor in this process.
Article Abstract
The role of the Epstein-Barr virus in the development of post-transplant lymphomas is well established. However, not all lymphomas that arise in these patients contain Epstein-Barr virus, suggesting that other cofactors are involved in tumor pathogenesis. We propose that immunologic interactions that result from the introduction of immunocompetent donor cells during transplantation contribute to a lymphomagenic environment in the host. Murine models of lymphoma that arises following transfer of allogeneic hematopoietic cells are discussed and are related to the transplant setting. One contemporary viewpoint of transplantation immunology holds that interactions between the host and donor components of the immune system determine the ultimate degree of tolerance or reciprocal immunoreactivity (eg, rejection, graft-versus-host disease) within the transplant patient. We conclude that host-donor immunologic microchimerism may also be an over-looked factor in the development of posttransplant lymphomas.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002071 | PMC |
| http://dx.doi.org/10.1097/00075200-199710000-00007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!