Resistance to antituberculosis drugs is due to the occurrence of resistant mutants in the bacterial population even before exposure to these drugs. These mutations are chromosomal in origin. Resistance occurs when the bacterial population is large or when drugs are used alone. Potent drugs such as rifampicin, isoniazid and streptomycin are effective in preventing emergence of resistance. Resistance to isoniazid and streptomycin was found to have minimal influence on response to short-course chemotherapy. On the other hand rifampicin resistance was associated with a high failure rate. Control of resistance is important to maintain the success of short-course chemotherapy. The restriction of the use of rifampicin to treatment of tuberculosis in combined drug regimens will reduce the occurrence of resistance to this essential drug.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/1120009x.1990.11739007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Leptospirosis, melioidosis, and rickettsioses in the vicious circle of neglect.
PLoS Negl Trop Dis
January 2025
Center for Infection and Molecular Medicine, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.
The global priorities in the field of infectious diseases are constantly changing. While emerging viral infections have regularly dominated public health attention, which has only intensified after the COVID-19 pandemic, numerous bacterial diseases have previously caused, and continue to cause, significant morbidity and mortality-deserving equal attention. Three potentially life-threatening endemic bacterial diseases (leptospirosis, melioidosis, and rickettsioses) are a huge public health concern especially in low- and middle-income countries.
View Article and Find Full Text PDFIron limitation triggers roseoceramide biosynthesis and membrane remodeling in marine roseobacter.
Proc Natl Acad Sci U S A
January 2025
Department of Chemistry, Princeton University, Princeton, NJ 08544.
Chemical communication between marine bacteria and their algal hosts drives population dynamics and ultimately determines the fate of major biogeochemical cycles in the ocean. To gain deeper insights into this small molecule exchange, we screened niche-specific metabolites as potential modulators of the secondary metabolome of the roseobacter, . Metabolomic analysis led to the identification of a group of cryptic lipids that we have termed roseoceramides.
View Article and Find Full Text PDFOptimizing proinsulin production in E. coli BL21 (DE3) using taguchi method and efficient one-step insulin purification by on-column enzymatic cleavage.
Braz J Microbiol
January 2025
Faculty of Material Science and Engineering, K. N. Toosi University of Technology, Tehran, Iran.
Diabetes is a critical worldwide health problem. Numerous studies have focused on producing recombinant human insulin to address this issue. In this research, the process factors of production of recombinant His-tagged proinsulin in E.
View Article and Find Full Text PDFLD-transpeptidase-mediated cell envelope remodeling enables developmental transitions and survival in and .
J Bacteriol
January 2025
Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, New York, USA.
and are two phylogenetically related bacterial pathogens that exhibit extreme intrinsic resistance when they enter into a dormancy-like state. This enables both pathogens to survive extended periods in growth-limited environments. Survival is dependent upon their ability to undergo developmental transitions into two phenotypically distinct variants, one specialized for intracellular replication and another for prolonged survival in the environment and host.
View Article and Find Full Text PDFStructural insights into the role of the prosegment binding loop in a papain-superfamily cysteine protease from Treponema denticola.
Acta Crystallogr F Struct Biol Commun
February 2025
Department of Structural Biology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA.
Periodontal diseases afflict 20-50% of the global population and carry serious health and economic burdens. Chronic periodontitis is characterized by inflammation of the periodontal pocket caused by dysbiosis. This dysbiosis is coupled with an increase in the population of Treponema denticola, a spirochete bacterium with high mobility and invasivity mediated by a number of virulence factors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!