J Environ Sci Health B
Environmental and Occupational Toxicology Division, Bureau of Chemical Hazards, Ottawa, Ontario.
Published: April 1990
Chlorinated diphenyl ethers (CDE's) are environmental contaminants that have been found in Great Lakes fish. Because of the paucity of toxicity data and potential for human exposure, the present short-term study was conducted to assess their potential toxic effects. Groups of 10 male and 10 female rats were administered the three CDE congeners (2,2',4,4',5-pentachlorodiphenyl ether (PCDE), 2,2',4,4',5,5'-hexachlorodiphenyl ether (HCDE), 2,2',3,4,4',6,6'-heptachlorodiphenyl ether (HPCDE] in diets at levels of 0.5, 5.0, 50 or 500 ppm for a period of 4 weeks. Decreased food consumption was observed with male and female rats fed the diet containing 500 ppm HPCDE. Treatment with the three isomers at the highest dose level produced an increase in liver weight in both sexes. While administration of PCDE produced an increase in hepatic aminopyrine demethylase activity, HCDE caused a significant increase in aminopyrine demethylase, aniline hydroxylase and ethoxyresorufin de-ethylase activities. HPCDE caused a significant increase in ethoxyresorufin de-ethylase activity. HPCDE at the highest dose level also caused a significant reduction in circulating lymphocytes in male rats. The 3 CDE's produced mild and adaptative histological changes in the liver and thyroid, but only HPCDE elicited mild changes in the thymus, bone marrow, and spleen. The above data indicate that HPCDE is immunosuppressive and that all three CDE isomers are considered to be moderately toxic in rats. The no-observable effects levels appear to be between 5-50 ppm in diet (0.36-3.0 mg/kg b.w.) for the three CDE's.
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http://dx.doi.org/10.1080/03601239009372686 | DOI Listing |
J Food Prot
January 2025
Universitat Rovira i Virgili Laboratory of Toxicology and Environmental Health, School of Medicine, 43201, Reus, Catalonia, Spain. Electronic address:
Polychlorinated diphenyl ethers (PCDEs) are a class of chlorinated aromatic compounds with structural similarities to polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs). Due to their physicochemical properties, PCDEs are highly resistant to degradation and tend to accumulate in soils, sediments, and aquatic organisms, making them capable of entering and persisting in the food chain. As with other persistent organic pollutants (POPs), diet represents the primary route of human exposure to PCDEs.
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February 2025
Department of Civil and Environmental Engineering, Pusan National University, Busan 46241, Republic of Korea; Institute for Environment and Energy, Pusan National University, Busan, 46241, Republic of Korea. Electronic address:
Chemosphere
February 2025
Bursa Technical University, Department of Environmental Engineering, Bursa, Turkiye. Electronic address:
The pollution potential of a municipal wastewater treatment plant (WWTP) in Bursa, Türkiye, in terms of organochlorine pesticides (ΣOCPs), polychlorinated biphenyls (ΣPCBs), and polybrominated diphenyl ethers (ΣPBDEs), was investigated in air samples. Concentrations were determined using polyurethane foam disk samplers at key processes, such as the aeration tank (AT) and settling chamber (SC) of the WWTP and the background area (BA) at an urban site. Atmospheric concentration levels of PBDEs at the SC are 1.
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February 2025
University of North Texas, Department of Biological Sciences and Advanced Environmental Research Institute, Denton, TX, 76203, USA. Electronic address:
The goal of this study was to compare the bioaccumulation of the PCB mixture Aroclor 1254 in zebrafish to cardiac and neurologic outcomes. The establishment of effect concentrations (ECs) for cardiac and neurotoxic effects of PCBs in early life stage fish is challenging due to a lack of measured PCB concentrations in test media (e.g.
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January 2025
University of Hohenheim, Institute of Food Chemistry, Department of Food Chemistry (170b), D-70599 Stuttgart, Germany. Electronic address:
Methoxylated polybrominated diphenyl ethers (MeO-BDEs) are a class of environmentally relevant halogenated natural products. The two most relevant isomers, 2'-MeO-BDE 68 and 6-MeO-BDE 47, were repeatedly detected at levels comparable with persistent organic pollutants in marine environmental and food samples. MeO-BDEs were suspected to be biosynthesized by bromoperoxidases through the merging of two bromophenol units, three of which (2,4-dibromophenol, 2,6-dibromophenol and 2,4,6-tribromophenol) are abundant in marine environments, followed by O-methylation to give MeO-BDEs.
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