AI Article Synopsis
- The study introduces a new imaging technique called Angular Domain Fluorescence Lifetime Imaging (ADFLI) that uses an angular filter array to detect light from fluorescent molecules.
- ADFLI can effectively capture minimally scattered light from depths of up to 2 mm in turbid media, making it valuable for imaging in complex biological tissues.
- Results show that ADFLI improves spatial resolution and image contrast for fluorescent probes compared to traditional lens and pinhole systems when imaging tissue-like materials.
Article Abstract
We describe a fluorescence lifetime imaging technique employing the collimation detection capabilities of an angular filter array (AFA). The AFA accepts minimally scattered photons emitted from fluorophores up to 2 mm deep within turbid media. The technique, referred to as Angular Domain Fluorescence Lifetime Imaging (ADFLI), is described and its performance evaluated in comparison to a conventional (lens and pinhole) system. Results from a tissue-mimicking phantom demonstrated that ADFLI provides better spatial resolution and image contrast for fluorescent probes at greater depths compared to a lens and pinhole system.
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| http://dx.doi.org/10.1364/OE.18.023247 | DOI Listing |
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