Hypertrophic discoid lupus erythematosus is a distinct form of chronic cutaneous (discoid) lupus, which is characterized by hyperkeratotic plaques that typically are observed over the face, arms, and upper trunk. We present the case of a 43-year-old man with verrucous plaques that were distributed symmetrically over the face, who initially was treated with oral antibiotics and topical glucocorticoids for acne vulgaris. A biopsy specimen confirmed the diagnosis of hypertrophic discoid lupus erythematosus. The clinical and histopathologic features of this clinical variant are reviewed.
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Cureus
November 2024
Rheumatology, Cooper University Health Care, Camden, USA.
Drug-induced lupus erythematosus (DILE) is an autoimmune reaction that results in symptoms of polyarthralgia, fever, and cutaneous lesions and other manifestations. Several drugs have been documented to cause this disease, including procainamide, isoniazid, methyldopa, penicillamine, and hydralazine. Systemic lupus erythematosus (SLE) manifestations often occur after the patient has been taking the drug without complications for months to years.
View Article and Find Full Text PDFJAAD Case Rep
December 2024
Department of Dermatology, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia.
J Coll Physicians Surg Pak
December 2024
Department of Rheumatology and Nephrology, Huabei Petroleum Administration Bureau General Hospital, Renqiu, China.
To uncover the clinical characteristics and investigate the underlying causes of psychiatric manifestations in patients with systemic lupus erythematosus (SLE), including its subset, neuropsychiatric systemic lupus erythematosus (NPSLE). Through comprehensive database searches in PubMed, Embase, Medline, and Cochrane, from their inception to August 2023, the study focused on adult SLE and NPSLE cases. From the selected studies, data were synthesised via a random-effects meta-analysis, encompassing a total of 2,997 subjects across six studies.
View Article and Find Full Text PDFCureus
October 2024
Dermatology, Shanghai Skin Disease Hospital , Tongji University, Shanghai, CHN.
Discoid lupus erythematosus is an autoimmune disease. When the disease manifests in multiple sites, it is classified as disseminated discoid lupus erythematosus. It is challenging for dermatologists to distinguish this condition from other erythematous diseases, and it is sometimes misdiagnosed as psoriasis.
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