Objective: To understand the pattern of children injuries treated in hospitals and to provide evidence for its further prevention and control.
Methods: Data of children cases was descriptively analyzed from the Chinese National Injury Surveillance System (NISS), from 2006 to 2008.
Results: The incidence rates of boys were twice (2.22, 2.15, 2.15) higher than girls. About one half (50.74%, 49.75%, 49.75%) of them were 5-14 year of age. The main causes were falls (44.14%, 45.68%, 47.15%), RTIs (15.71%, 14.46%, 13.79%), and blunt force injuries (13.20%, 12.92%, 12.40%). Main locations where the injuries happened were at home (34.96%, 36.86%, 38.84%), school and public places (24.72%, 19.80%, 21.19%), and road/street (21.21%, 19.63%, 19.33%). The major injured body parts were head (34.88%, 35.84%, 37.07%), upper limbs (28.00%, 28.21%, 27.81%) and lower limbs (21.86%, 21.49%, 21.31%). The majority cases were unintentional (93.01%, 92.66%, 90.58%), minor (78.50%, 81.20%, 81.52%) injuries, treated and discharged (82.37%, 85.19%, 84.84%). There were considerable differences in the distributions of causes, locations, injured body parts, and other contexts depending on age.
Conclusion: The pattern of children's injury would include causes, places and other characteristics treated at hospitals from NISS and was related to the age of the injured child which was quite different from the spectrum of death caused by injury. NISS acts as an important source of information on children's injury in China, and can contribute to the prevention and control program on children's injury.
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Cell Death Dis
January 2025
Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
The involvement of B lymphocytes in the pathogenesis of rheumatoid arthritis (RA) is well-established, with their early and aberrant activation being a crucial factor. However, the mechanisms underlying this abnormal activation in RA remain incompletely understood. In this study, we identified a significant reduction in MAPK4 expression in both RA patients and collagen-induced arthritis (CIA) mouse models, which correlates with disrupted B cell activation.
View Article and Find Full Text PDFZhonghua Nei Ke Za Zhi
February 2025
Department of Critical Care Medicine, the First Hospital of Tsinghua University, Beijing100016, China.
Turning to critical illness is a common stage of various diseases and injuries before death. Patients usually have complex health conditions, while the treatment process involves a wide range of content, along with high requirements for doctor's professionalism and multi-specialty teamwork, as well as a great demand for time-sensitive treatments. However, this is not matched with critical care professionals and the current state of medical care in China.
View Article and Find Full Text PDFBMJ Case Rep
January 2025
General Surgery, Toowoomba Hospital, Toowoomba, Queensland, Australia.
While internal hernias are rare in the paediatric population, it should be considered as a cause for an acute abdomen following blunt trauma. Internal hernias represent a surgical emergency that requires prompt recognition due to the high risk of strangulation and ischaemia of affected bowel loops. The case of a transomental hernia (TOH) is described in a young girl.
View Article and Find Full Text PDFAnn Vasc Surg
January 2025
Department of Surgery, University Hospital Centre Zagreb, Zagreb, Croatia.
Objectives: Brachial artery injury due to displaced supracondylar fracture (SC) of the humerus in children may present with pink pulseless hand (PPH), denoting a well perfused hand without radial pulse, or acute hand ischemia. Some reports state that brachial artery reconstruction is not necessary in children with persisting PPH, but the reports on long-term consequences such as intermittent claudications, growth retardation and ischemic contracture in children with pulseless hand are scarce and often misinterpreted. The objective of our analysis was to assess the long-term outcomes of children with brachial artery injury associated with SC fracture.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Department of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu, People's Republic of China. Electronic address:
After spinal cord injury (SCI), reactive astrocytes in the injured area are triggered after spinal cord injury (SCI) and to polarize into A1 astrocytes with a proinflammatory phenotype or A2 astrocytes with an anti-inflammatory phenotype. Monopolar spindle binder 2 (MOB2) induces astrocyte stellation, maintains cell homeostasis, and promotes neurite outgrowth; however, its role in the phenotypic transformation of reactive astrocytes remains unclear. Here, we confirmed for the first time that MOB2 is associated with A1/A2 phenotypic switching in reactive astrocytes following SCI in mice.
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