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Insulin-like growth factor-1 and insulin inhibit caspase-3/7 activation initiated by interleukin-1β in the rat eye retinal neurons. | LitMetric
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Insulin-like growth factor-1 and insulin inhibit caspase-3/7 activation initiated by interleukin-1β in the rat eye retinal neurons.

S S Shushanov

Bull Exp Biol Med

Institute of Carcinogenesis, N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow.

Published: December 2010

Proinflammatory cytokine IL-1β specifically stimulates caspase-3/7 in vitro in RGC-5 rat eye retinal neurons. Insulin and insulin-like growth factor-1 and their combination inhibit caspase-3/7 activation in these cells, induced by removal of the serum from culture medium and/or by IL-1β treatment.

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http://dx.doi.org/10.1007/s10517-010-1063-4DOI Listing

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