AI Article Synopsis
- A 77-year-old woman with chronic hepatitis B became resistant to lamivudine and started on adefovir treatment while continuing lamivudine.
- After four months, her liver function improved, and her HBV-DNA levels were undetectable.
- Despite the improved liver function, she developed hepatocellular carcinoma three years later, which was successfully treated with surgery, indicating adefovir's benefit in managing liver health but not preventing cancer.
Article Abstract
We describe a 77-year-old woman with chronic hepatitis B who became resistant to lamivudine. She was started on adefovir (10 mg daily) while still continuing lamivudine therapy. Four mo later her liver function improved and serum Hepatitis B virus (HBV)-DNA level became undetectable. Three years after the start of additional adefovir treatment, hepatocellular carcinoma (HCC) was detected and the patient underwent a successful hepatectomy. Our findings suggest that the addition of adefovir to ongoing lamivudine therapy cannot completely suppress hepatocarcinogenesis, but is useful for improving liver function in patients with lamivudine-resistant HBV-related cirrhosis, allowing HCC surgery.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998976 | PMC |
| http://dx.doi.org/10.4254/wjh.v2.i8.318 | DOI Listing |
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