AI Article Synopsis
- Early detection of hepatocellular carcinoma (HCC) has increased globally due to surveillance programs targeting individuals with cirrhosis.
- Advancements in non-invasive imaging technologies, such as harmonic ultrasound and MRI, have improved diagnostic accuracy, leading to a decreased reliance on liver biopsies.
- New developments in genomics and proteomics have identified potential serum and tissue markers that could enhance HCC diagnosis and prognosis, possibly revitalizing the need for liver biopsies.
Article Abstract
Early identification of hepatocellular carcinoma (HCC) is more frequent because of surveillance programs for HCC worldwide. The optimal strategy of surveillance in cirrhosis is a current topical issue. In terms of diagnosis, recent advances in non-invasive imaging technology, including various techniques of harmonic ultrasound, new ultrasound contrast agents, multi-slice helical computed tomography and rapid high quality magnetic resonance, have all improved the accuracy of diagnosis. Consequently the role of liver biopsy in diagnosis of HCC has declined. The imaging diagnosis relies on the hallmark of arterial hypervascularity with portal venous washout. However, with recent advances in genomics and proteomics a great number of potential serum and tissue markers have been identified and are being developed as new candidate markers for both diagnosis and prognosis of hepatocellular carcinoma, and may increase the need for liver biopsy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998953 | PMC |
| http://dx.doi.org/10.4254/wjh.v1.i1.48 | DOI Listing |
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