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Unlocking the therapeutic potential of the NFAT pathway in kidney diseases.
Naunyn Schmiedebergs Arch Pharmacol
March 2025
Department of Pharmacy, Birla Institute of Technology and Science, Pilani Campus, Pilani, Rajasthan, 333031, India.
The nuclear factor of activated T cells (NFAT) is a novel renoprotective transcription factor in an inactive form in the cytoplasm and an active form in the nucleus. NFAT is expressed in T cells, heart, kidney and lymphocytes. NFAT plays an essential role in inducing apoptosis of renal tubular epithelial cells.
View Article and Find Full Text PDFFerroptosis, necroptosis, and pyroptosis in calcium oxalate crystal-induced kidney injury.
Biochim Biophys Acta Mol Basis Dis
March 2025
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Kidney stones represent a highly prevalent urological disorder worldwide, with high incidence and recurrence rates. Calcium oxalate (CaOx) crystal-induced kidney injury serves as the foundational mechanism for the formation and progression of CaOx stones. Regulated cell death (RCD) such as ferroptosis, necroptosis, and pyroptosis are essential in the pathophysiological process of kidney injury.
View Article and Find Full Text PDFCalcium-sensing receptor genetic variants and their association with CKD-MBD in South Indian Tamils.
J Appl Genet
March 2025
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006, India.
The progressive degradation of the renal parenchyma and reduction of functional nephrons characterise chronic kidney disease (CKD). Disorders of bone mineral metabolism is one of the leading causes of morbidity and mortality in CKD. Calcium-sensing receptor (CASR) allows cells to detect changes in blood calcium levels and regulate its concentration.
View Article and Find Full Text PDFEfficacy and Safety of Phosphate-Lowering Agents for Adult Patients with Chronic Kidney Disease Requiring Dialysis: A Network Meta-Analysis.
Clin J Am Soc Nephrol
March 2025
Division of Nephrology, Endocrinology, and Metabolism, Tokai University School of Medicine, Kanagawa, Japan.
Background: It is necessary to update the evidence of each phosphate-lowering agent on dialysis patients.
Methods: From the CENTRAL, MEDLINE, EMBASE, and ClinicalTrial.gov databases, randomized controlled trials (RCTs) using oral phosphate-lowering agents on adult patients requiring maintenance dialysis were extracted.
Thrombospondin-1 binds to integrin β3 to inhibit vascular calcification through suppression of NF-κB pathway.
J Pathol
March 2025
Department of Cardiology, Laboratory of Heart Center, Heart Center, Zhujiang Hospital, Southern Medical University, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation; Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, Guangzhou, PR China.
Vascular calcification is an important risk factor related to all-cause mortality of cardiovascular events in patients with chronic kidney disease (CKD). Vascular extracellular matrix (ECM) proteins have been demonstrated to regulate vascular calcification. ECM protein thrombospondin 1 (THBS1/TSP-1) plays a critical role in the regulation of vascular diseases.
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