AI Article Synopsis
- Researchers studied serum angiotensin-converting enzyme (ACE) activity and lysozyme (LZM) concentration in patients with silicosis and asbestosis, comparing them to patients with sarcoidosis.
- All groups showed significantly elevated ACE and LZM levels, with untreated sarcoidosis patients having the highest values.
- The finding of raised ACE levels in silicosis and asbestosis, previously unreported, complicates the use of ACE as a diagnostic tool for sarcoidosis and indicates a potential shared source for the enzyme changes across these diseases.
Article Abstract
Serum angiotensin-converting enzyme (ACE) activity and lysozyme (LZM) concentration in 22 silicosis and 18 asbestosis patients were studied. These patients were compared with 57 untreated and 36 treated sarcoidosis patients. In all groups significantly raised ACE and LZM mean values were noted. Untreated sarcoidosis patients had the highest values. Raised ACE activity in silicosis and asbestosis has not been reported before, and weakens the differential diagnostic value of this enzyme determination for sarcoidosis. The similar patterns of increased ACE and LZM mean values in all three diseases suggest that these enzymes have a common source.
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