Multi-parameter determination of TNFα, PCT and CRP for point-of-care testing.

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Helmholtz Zentrum München-German Research Center for Environmental Health, Institute of Ecological Chemistry, Neuherberg, Oberschleissheim, Germany.

Published: February 2011

A proof of concept for the simultaneous multi-parameter determination of three inflammation and sepsis parameters-TNFα, PCT and CRP-using a compact optical immunosensor is demonstrated. Harmonized assay conditions revealed standard curves with test midpoints (IC(50)) of 380 µg L(-1) for TNFα, 2300 µg L(-1) for PCT, and 2645 µg L(-1) for CRP.

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http://dx.doi.org/10.1039/c0an00699hDOI Listing

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