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Loss of Pla2r1 decreases cellular senescence and age-related alterations caused by aging and Western diets.
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Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Cellular senescence is induced by many stresses including telomere shortening, DNA damage, oxidative, or metabolic stresses. Senescent cells are stably cell cycle arrested and they secrete many factors including cytokines and chemokines. Accumulation of senescent cells promotes many age-related alterations and diseases.
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National Health Service Blood and Transplant (NHSBT), Tissue and Eye Services, Research and Development, Liverpool, UK.
Introduction: NHS Blood and Transplant Tissue and Eye Services (TES) retrieve eyes for corneal and scleral transplant purposes from hospitals, hospices, and funeral homes throughout the UK. The eyes are sent to TES eye banks either in Liverpool or Bristol. A major objective of TES is to ensure that the eyes arrive at their destinations in good condition and remain fit for purpose.
View Article and Find Full Text PDFQuantification of the hepatitis B virus cccDNA: evidence-based guidelines for monitoring the key obstacle of HBV cure.
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Objectives: A major goal of curative hepatitis B virus (HBV) treatments is the reduction or inactivation of intrahepatic viral covalently closed circular DNA (cccDNA). Hence, precise cccDNA quantification is essential in preclinical and clinical studies. Southern blot (SB) permits cccDNA visualisation but lacks sensitivity and is very laborious.
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Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Globally, 296 million people are infected with hepatitis B virus (HBV), and approximately one million people die annually from HBV-related causes, including liver cancer. Although there is a preventative vaccine and antiviral therapies suppressing HBV replication, there is no cure. Intensive efforts are under way to develop curative HBV therapies.
View Article and Find Full Text PDFNivolumab-Induced Myasthenia Gravis Concomitant With Myocarditis, Myositis, and Hepatitis.
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We report a case of myasthenia gravis, myocarditis, and myositis following the treatment of melanoma with nivolumab. The patient was a 68-year-old Caucasian male with stage 3 melanoma status after two doses of nivolumab with shortness of breath, intermittent palpitations, dizziness, and nausea. During his initial evaluation, he was found to have atrial fibrillation with rapid ventricular response along with new-onset proximal muscle weakness, double vision, dysphagia, and ptosis of the right eye.
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