In this issue of Cancer Cell, Rui et al. identify JAK2 and JMJDC2 as two contiguous, coamplified oncogenes in primary mediastinal B cell and Hodgkin lymphoma. Together, JAK2 and JMJD2C induce major changes in chromatin structure and gene expression. Targeting these proteins with small molecules represents a new avenue for therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032418 | PMC |
| http://dx.doi.org/10.1016/j.ccr.2010.11.032 | DOI Listing |
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