AI Article Synopsis
- The apocrine secretory mechanism involves the pinching off of the cell's apical cytoplasm to form a structure called an aposome, but its detailing has not been extensively studied.
- Researchers investigated proteins linked to cytokinesis in human axillary apocrine glands, finding several proteins (like actin and myosin II) associated with the process.
- Their results suggest that the final steps of apocrine secretion resemble cytokinesis, potentially regulated by SNARE-mediated membrane fusion, providing new insights into how these glands function.
Article Abstract
The apocrine secretory mechanism is a mode of secretion by which the apical part of the cell cytoplasm is pinched off, which leads to the formation of an aposome. The distinct mechanism of formation and decapitation of the aposome is not well investigated. Only few proteins are known that are involved in this secretory mechanism. We studied the human axillary apocrine gland and looked at proteins associated with cytokinesis, a process that is comparable to the pinching-off mechanism of apocrine glandular cells. By immunohistochemistry, we detected actin, myosin II, cytokeratin 7 and 19, α- and β-tubulin, anillin, cofilin, syntaxin 2, vamp8/endobrevin and septin 2. In highly active glandular cells, these proteins are located at the base of the apical protrusion when the aposome is in the process of being released or are concentrated in the cap of the apical protrusion. These findings demonstrate new insights on apocrine secretory mechanisms and point to similarities to the terminal step of cytokinesis, which is regulated by a SNARE-mediated membrane fusion event.
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| http://dx.doi.org/10.14670/HH-26.177 | DOI Listing |
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