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Tandem LIM domain-containing proteins, LIMK1 and LMO1, directly bind to force-bearing keratin intermediate filaments.
Cell Rep
July 2024
Biomedical Engineering Department, University of California, Davis, Davis CA 95616, USA. Electronic address:
The cytoskeleton of the cell is constantly exposed to physical forces that regulate cellular functions. Selected members of the LIM (Lin-11, Isl-1, and Mec-3) domain-containing protein family accumulate along force-bearing actin fibers, with evidence supporting that the LIM domain is solely responsible for this force-induced interaction. However, LIM domain's force-induced interactions are not limited to actin.
View Article and Find Full Text PDFSulforaphane Inhibits Adhesion and Migration of Cisplatin- and Gemcitabine-Resistant Bladder Cancer Cells In Vitro.
Nutrients
February 2024
Department of Urology and Pediatric Urology, University Medical Center Mainz, 55131 Mainz, Germany.
Only 20% of patients with muscle-invasive bladder carcinoma respond to cisplatin-based chemotherapy. Since the natural phytochemical sulforaphane (SFN) exhibits antitumor properties, its influence on the adhesive and migratory properties of cisplatin- and gemcitabine-sensitive and cisplatin- and gemcitabine-resistant RT4, RT112, T24, and TCCSUP bladder cancer cells was evaluated. Mechanisms behind the SFN influence were explored by assessing levels of the integrin adhesion receptors β1 (total and activated) and β4 and their functional relevance.
View Article and Find Full Text PDFInfluence of Tumor Stroma on the Aggressiveness of Poorly Cohesive Gastric Carcinoma.
J Pers Med
February 2024
Unit of General and Upper GI Surgery, University of Verona, 37126 Verona, Italy.
Article Synopsis
- The study investigates how the stroma (connective tissue) surrounding poorly cohesive gastric cancer (PCGC) affects cancer cell adaptation and patient outcomes.
- Researchers classified 75 PCGC specimens as stroma-rich (SR) or stroma-poor (SP) and found that SR tumors are linked to deeper tumor invasion and worse survival rates compared to SP tumors.
- Additionally, mRNA analysis showed that KRT8 levels correlate with tumor behavior, where KRT8-high tumors had better survival outcomes, highlighting the role of stromal content and extracellular proteins in determining tumor aggression and patient prognosis.
Keratin Expression in Podocytopathies, ANCA-Associated Vasculitis and IgA Nephropathy.
Int J Mol Sci
February 2024
Department of Nephrology and Kidney Transplantation, University Hospital of Patras, 26504 Patras, Greece.
Keratins are the main components of the cell cytoskeleton of epithelial cells. Epithelial cells under stressful stimuli react by modifying their keratin expression pattern. Glomerular diseases are pathological conditions that may lead to loss of kidney function if not timely diagnosed and treated properly.
View Article and Find Full Text PDFDifferential distribution of intermediate filament proteins in the bovine and ovine tongues.
Anat Histol Embryol
January 2024
Department of Histology and Embryology, Faculty of Veterinary Medicine, Dicle University, Diyarbakır, Turkey.
Intermediate filaments constitute the most heterogeneous class among the major classes of cytoskeletal proteins of mammalian cells. The 40 or more intermediate filament proteins have been classified into five types which show very specific rules of expression in specialized cell types. This study aimed to investigate the immunohistochemical distribution of cytokeratins (CKs) 8, 18, and 19 as well as the intermediate filaments vimentin, laminin, and desmin in bovine and ovine tongues.
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