AI Article Synopsis
- The study aimed to manage dysfunctional uterine bleeding (DUB) by grouping patients based on their endometrial thickness and applying different treatments.
- A retrospective review of 49 patients showed significant reductions in bleeding days after treatment: combined OCPs dropped bleeding from 46 to 8 days, estrogen plus progesterone from 41 to 9 days, and megestrol from 54 to 3 days.
- The findings suggest that treatment based on endometrial thickness is effective, although 52% of those treated with megestrol had endometrial hyperplasia, indicating a need for further monitoring.
Article Abstract
Objective: To manage patients with dysfunctional uterine bleeding (DUB) according to endometrial thickness.
Methods: A retrospective chart review of 49 patients who reported 8 or more days of bleeding was performed. They were then divided into three groups based on endometrial thickness (mm): less than 6, 6-11, and greater than 11. These three groups were treated with combined oral contraceptive pills (OCP), conjugated estrogen plus progesterone and megestrol respectively. Patients given megestrol also underwent endometrial biopsy before treatment. Patients recorded the degree of bleeding each day for one month after starting treatment.
Results: Mean endometrial thickness in the combined OCPs, conjugated estrogen plus progesterone and megestrol groups were 4, 8 and 14 mm, respectively. Combined OCPs decreased bleeding from 46 to 8 days (P < 0.05, n = 8). Conjugated estrogen plus progesterone decreased the number of days of bleeding from a mean of 41 to 9 (P < 0.01, n = 16). Megestrol decreased bleeding from 54 to 3 days (P < 0.001, n = 25). 52% of patients given megestrol had endometrial hyperplasia.
Conclusion: These results support the effectiveness of treating patients with DUB according to endometrial thickness.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990898 | PMC |
| http://dx.doi.org/10.2147/IJWH.S11531 | DOI Listing |
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