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High-resolution transcranial optical imaging of in vivo neural activity.
Sci Rep
October 2024
John Hopkins University Applied Physics Laboratory, Laurel, MD, 20723, USA.
Rapid sub-nanometer neuronal deformations have been shown to occur as a consequence of action potentials in vitro, allowing for optical registration of discrete axonal and synaptic depolarizations. Such optically-measured deformations are a novel signature for recording neural activity. We demonstrate this signature can be extended to in vivo measurements through recording of rapid neuronal deformations on the population level with holographic, optical phase-based recordings.
View Article and Find Full Text PDFAnesthetics inhibit phosphorylation of the ribosomal protein S6 in mouse cultured cortical cells and developing brain.
Front Aging Neurosci
May 2023
Laboratory for Aging Neuroscience, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, United States.
Introduction: The development and maintenance of neural circuits is highly sensitive to neural activity. General anesthetics have profound effects on neural activity and, as such, there is concern that these agents may alter cellular integrity and interfere with brain wiring, such as when exposure occurs during the vulnerable period of brain development. Under those conditions, exposure to anesthetics in clinical use today causes changes in synaptic strength and number, widespread apoptosis, and long-lasting cognitive impairment in a variety of animal models.
View Article and Find Full Text PDFParadoxical markers of conscious levels: Effects of propofol on patients in disorders of consciousness.
Front Hum Neurosci
October 2022
Montreal General Hospital, McGill University Health Centre, Montreal, QC, Canada.
Human consciousness is widely understood to be underpinned by rich and diverse functional networks, whose breakdown results in unconsciousness. Candidate neural correlates of anesthetic-induced unconsciousness include: (1) disrupted frontoparietal functional connectivity; (2) disrupted brain network hubs; and (3) reduced spatiotemporal complexity. However, emerging counterexamples have revealed that these markers may appear outside of the state they are associated with, challenging both their inclusion as markers of conscious level, and the theories of consciousness that rely on their evidence.
View Article and Find Full Text PDFRopivacaine-induced seizures evoked pain sensitization in rats: Participation of 5-HT/5-HT3R.
Neurotoxicology
December 2022
Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, PR China. Electronic address:
Due to the increasing use of local anesthetic techniques in various healthcare settings, local anesthetic toxicity still occurs. Seizures are the most common symptom of local anesthetic toxicity. The relationship between local anesthetic-induced seizures and the sensation of pain has not been established till now.
View Article and Find Full Text PDFDynamic alpha-gamma phase-amplitude coupling signatures during sevoflurane-induced loss and recovery of consciousness.
Neurosci Res
December 2022
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310027, China. Electronic address:
Phase-amplitude coupling (PAC) plays an important role in anesthetic-induced unconsciousness. The delta-alpha PAC signature during anesthetic-induced unconsciousness is gradually becoming known; however, the frequency dependence and spatial characteristics of PAC are still unclear. Multi-channel electroencephalography (EEG) was performed during the loss and recovery phases of consciousness in patients undergoing general anesthesia using sevoflurane.
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