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Recent studies have revealed that many mosquito species regularly engage in high-altitude windborne migration, but its epidemiological significance was debated. The hypothesis that high-altitude mosquitoes spread pathogens over large distances has not been directly tested. Here, we report for the first time that high-altitude windborne mosquitoes are commonly infected with arboviruses, protozoans, and helminths affecting vertebrates and humans, and provide the first description of this pathogen-vector aerial network.
View Article and Find Full Text PDFPreventing alpelisib-related hyperglycaemia in HR+/HER2-/-mutated advanced breast cancer using metformin (METALLICA): a multicentre, open-label, single-arm, phase 2 trial.
EClinicalMedicine
May 2024
Medica Scientia Innovation Research (MEDSIR), Barcelona, Spain.
Background: Hyperglycaemia is an early and frequent adverse event during alpelisib treatment. METALLICA aimed to evaluate prophylactic metformin to prevent or reduce hyperglycaemia occurrence in patients with HR+/HER2-/-mutated advanced breast cancer (ABC).
Methods: Between August 13th, 2020 and March 23rd, 2022, this 2-cohort, phase 2, multicentre, single-arm trial (NCT04300790) enrolled patients with HR+/HER2-/PIK3CA-mutated ABC: cohort A, normal glycaemia (fasting plasma glucose <100 mg/dL [<5.
Novel strains of Culex flavivirus and Hubei chryso-like virus 1 from the Anopheles mosquito in western Kenya.
Virus Res
January 2024
Department of Clinical Microbiology, Umeå University, Umeå 901-85, Sweden; Umeå Centre for Microbial Research, Umeå University, Umeå 901-87, Sweden.
Surveillance of mosquito vectors is critical for early detection, prevention and control of vector borne diseases. In this study we used advanced molecular tools, such as DNA barcoding in combination with novel sequencing technologies to discover new and already known viruses in genetically identified mosquito species. Mosquitoes were captured using BG sentinel traps in Western Kenya during May and July 2019, and homogenized individually before pooled into groups of ten mosquitoes.
View Article and Find Full Text PDF, a New Neotropical Jackal Fly Genus of Milichiidae (Insecta: Diptera) Associated with Carton Ant Nest.
Zool Stud
July 2023
Graduate Program in Entomology, Instituto Nacional de Pesquisas da Amazônia -INPA, Manaus, Amazonas, Brazil. E-mail: (Soares).
metallica gen. et sp. nov.
View Article and Find Full Text PDFThe present study enumerates 65 species of Papilionoidea from the Ladakh Himalaya with the geographical locations and adult flight data. All the species are documented by museum vouchers. Most of the species recorded, have restricted distribution or they are endemic to the Pamir-NW Himalaya region.
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