12 patients suffering from chronic renal failure did receive for 12 to 22 months a special protein-poor diet containing 20 g of high-class proteins and essential amino acids (4.8 g/d). During this period the serum levels of albumin, transferrin, immunoglobulins, hemoglobin and ferritin did remain unchanged, whereas the levels of C3 was reduced significantly. The glucose metabolism and the serum levels of cholesterol and triglycerids were constant. The results show no metabolic changes during long-term protein-poor diet containing minimal doses of essential amino acids.

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